Publications

Featured Publication:


"Unraveling the Pathogenesis of Crimean-Congo Hemorrhagic Fever: A Novel Approach via Non-Targeted Metabolomics by NMR Spectroscopy." (2023).

The application of metabolomics for studying modifications in host metabolism due to viral infections has proven to be a game-changing approach. Prior to our study, only one other ‘omics’ study has been carried out that investigates the interplay between the host and CCHFV and its subsequent pathogenesis. We employed NMR spectroscopy, given its advantages in terms of reproducibility, minimal sample preparation, and capability to analyze complex biofluids. Our methodology builds upon the proven success of metabolomics in the research of other viral hemorrhagic fevers such as Ebola, Marburg, and Dengue. Our research underlines the critical role of SAH, a metabolite involved in numerous biochemical reactions. We provide new insights into the metabolic alterations occurring in CCHF patients. These alterations not only shed light on the disease’s pathogenesis but also pave the way for potential biomarkers and therapeutic targets. Among all the metabolites detected, S-Adenosyl-L-homocysteine and Carnosine stood out as the most prevalent, warranting further exploration of their roles in CCHFV pathogenesis and their potential as therapeutic targets.

Dag, Cagdas, Oktay Göcenler, Kerem Kahraman, Derya Yapar, Yaren Kahraman, Cengizhan Büyükdag, Gülen Esken et al.

View 2006 - 2022 Publications 

482) Kumar, Umesh, Monika Sodhi, Dinesh Kumar, Prince Vivek, Saket K. Niranjan, Ranjit Singh Kataria, Sudarshan Kumar et al. "Characterizing metabolome signature of colostrum, transition and mature milk of indigenous cows (Bos indicus) adapted to high altitude environment of Leh-Ladakh." Food Chemistry (2024): 141767.

481) Chen, Guixia, Lifeng Chen, Huiya Wang, Jiyong Zhang, Xiaoling Sun, Xiaoxin Chen, Jianxia Fan, Zhiwei Jia, and Yinying Huang. "1H NMR-Based Metabolomic Profiling and Comparison of Human Milk Across Different Lactation Stages in Secretors and Non-Secretors: A Study of Chinese Lactating Women." The Journal of Nutrition (2024).

480) Kandasamy, Sujatha, Won-Seo Park, In-Seon Bae, Jayeon Yoo, Jeonghee Yun, Van-Ba Hoa, and Jun-Sang Ham. "HRMAS-NMR-Based Metabolomics Approach to Discover Key Differences in Cow and Goat Milk Yoghurt Metabolomes." Foods 13, no. 21 (2024): 3483.

479) Marokane-Radebe, Cynthia, Adekunle Raimi, Stephen Amoo, and Rasheed Adeleke. "Metabolomic profiling and 16 S rRNA metabarcoding of endophytes of two Aloe species revealed diverse metabolites." AMB Express 14, no. 1 (2024): 122.

478) Gowen, Niamh, Nan Gai, Seamus James A. O'Mahony, Jonathan O’Regan, and David Anthony Goulding. "Non-Protein Nitrogen in Dairy Ingredients: A Closer Look at its Contribution in Infant Nutritional Product Formulation." Jonathan and Goulding, David Anthony, Non-Protein Nitrogen in Dairy Ingredients: A Closer Look at its Contribution in Infant Nutritional Product Formulation.

477) Polcaro, Luciana Maria, Antonietta Cerulli, Milena Masullo, and Sonia Piacente. "Metabolomics of Withania somnifera L. extracts by an integrated LC-MS and NMR approach and evaluation of their tyrosinase inhibitory activity." Journal of Pharmaceutical and Biomedical Analysis (2024): 116520.

476) Hasan, Sk, Nafizul Alam, Gazi Abdullah Mashud, and Subodh Bhujel. "Neural Network for Enhancing Robot Assisted Rehabilitation: A Systematic Review." (2024).

475) D’Elia, Maria, Carmen Marino, Rita Celano, Enza Napolitano, Anna Maria D’Ursi, Mariateresa Russo, and Luca Rastrelli. "Impact of a Withania somnifera and Bacopa monnieri Formulation on SH-SY5Y Human Neuroblastoma Cells Metabolism Through NMR Metabolomic." (2024).

474) Laghi, Luca, Maria Àngels Ortiz, Giacomo Rossi, Eva Román, Carlo Mengucci, Elisabet Cantó, Lucia Biagini et al. "Biomarkers of Frailty in Patients with Advanced Chronic Liver Disease Undergoing a Multifactorial Intervention Consisting of Home Exercise, Branched-Chain Amino Acids, and Probiotics." Biomolecules 14, no. 11 (2024): 1410.

473) Katherinatama, Aldia, Yonathan Asikin, Kazuki Shimoda, Momoko Shimomura, Fumimasa Mitsube, Kensaku Takara, and Koji Wada. "Characterization of Free and Glycosidically Bound Volatile and Non-Volatile Components of Shiikuwasha (Citrus depressa Hayata) Fruit." Foods 13, no. 21 (2024): 3428.

472) Kumar, Sazal, Rafiquel Islam, Wayne O'Connor, Steve D. Melvin, Frederic DL Leusch, Allison Luengen, and Geoff R. MacFarlane. "A metabolomic analysis on the toxicological effects of the universal solvent, dimethyl sulfoxide." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology (2024): 110073.

471) Dağ, Çağdaş, and Kerem Kahraman. "Exploring the Biochemical Landscape of Bacterial Medium with Pyruvate as the Exclusive Carbon Source for NMR Studies." bioRxiv (2024): 2024-10.

470) Yang, Zhibo, Chuan Song, Qiuyu Lan, Bin Hu, Zonghua Ao, Xiaole Jiang, Suyi Zhang et al. "High-Throughput Metabolomics Reveals Effect of Glutathione-Enriched Inactive Dry Yeast on Volatile and Non-Volatile Compounds of Kiwi Wine." Available at SSRN 4979109.

469) Wang, Gangqi, Bernard M. van den Berg, Sarantos Kostidis, Kelsey Pinkham, Marleen E. Jacobs, Arthur Liesz, Martin Giera, and Ton J. Rabelink. "Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke." bioRxiv (2024): 2024-10.

468) Boisen, Gabriella, Susanne Brogårdh-Roth, Jessica Neilands, Alex Mira, Miguel Carda-Diéguez, and Julia R. Davies. "Oral biofilm composition and phenotype in caries-active and caries-free children." Frontiers in Oral Health 5 (2024): 1475361.

467) Msomi, Mhlonipheni, Garland More, Noluyolo Nogemane, and Gerhard Prinsloo. "1h-Nmr-Based Metabolomics and Antioxidant Enzymes of Maize (Zea Mays) in Response to Exogenously Applied Dicarboxylic Acids (Photon)." Available at SSRN 4891435.

466) McGivern, Bridget B., Jared B. Ellenbogen, David W. Hoyt, John A. Bouranis, Brooke P. Stemple, Rebecca A. Daly, Samantha H. Bosman et al. "Polyphenol rewiring of the microbiome reduces methane emissions." bioRxiv (2024): 2024-10.

465) Sink, Warren John, Russell Fling, Ali Yilmaz, Rance Nault, Delanie Goniwiecha, Jack Harkema, Stewart Graham, and Tim Zacharewski. "2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) elicited dose-dependent shifts in the murine urinary metabolome associated with hepatic AHR-mediated differential gene expression." bioRxiv (2024): 2024-10.

464) Quifer-Rada, Paola, Laia Aguilar-Camprubí, Sara Samino, Nuria Amigó, Oria Soler, and Alba Padró-Arocas. "Metabolomics Approach to Identify Biomarkers of Acute and Subacute Mastitis in Milk Samples: A Pilot Case–Control Study." Metabolites 14, no. 10 (2024): 566.

463) Dias, Ana S., Catarina R. Almeida, Luisa Helguero, and Iola F. Duarte. "Antitumoral Activity and Metabolic Signatures of Dichloroacetate, 6-Aminonicotinamide and Etomoxir in Breast-Tumor-Educated Macrophages." Journal of Proteome Research (2024).

462) Lu, Jie, Jiawen Wang, Tuo Yao, Shengli Fu, Xiao Hu, and Lingtong Ye. "Metabolomic and enzymatic markers reveal critical air exposure threshold for Crassostrea hongkongensis quality." Food Research International (2024): 115309.

461) Young, Megan, Malene Aastrup, Nikayla Patel, Fenn Cullen, Esben SS Hansen, James E. Clark, Thomas R. Eykyn et al. "Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes." bioRxiv (2024): 2024-10.

460) Brai, Annalaura, Cassia Neri, Franca Tarchi, Federica Poggialini, Chiara Vagaggini, Riccardo Frosinini, Sauro Simoni, Valeria Francardi, and Elena Dreassi. "Upcycling Milk Industry Byproducts into Tenebrio molitor Larvae: Investigation on Fat, Protein, and Sugar Composition." Foods 13, no. 21 (2024): 3450.

459) Martins, Cátia Falcão, Manolis Matzapetakis, David M. Ribeiro, Josipa Kuleš, Anita Horvatić, Nicholas Guillemin, Peter David Eckersall, João PB Freire, André M. Almeida, and José AM Prates. "Metabolomics and proteomics insights into hepatic responses of weaned piglets to dietary Spirulina inclusion and lysozyme supplementation." BMC Veterinary Research 20, no. 1 (2024): 505.

458) Casarrubios, Laura, Mónica Cicuéndez, Alberto Polo-Montalvo, María José Feito, Alvaro Martínez-del-Pozo, Daniel Arcos, Iola F. Duarte, and María Teresa Portolés. "Metabolomic characterization of MC3T3-E1pre-osteoblast differentiation induced by ipriflavone-loaded mesoporous nanospheres." Biomaterials Advances (2024): 214085.

457) Paglione, Marco, David CS Beddows, Anna Jones, Thomas Lachlan-Cope, Matteo Rinaldi, Stefano Decesari, Francesco Manarini et al. "Simultaneous organic aerosol source apportionment at two Antarctic sites reveals large-scale and eco-region specific components." Atmospheric Chemistry and Physics 24, no. 10 (2024): 6305-6322.

456) Li, Da-Wei, Rodrigo Cabrera Allpas, Munki Choo, Lei Bruschweiler-Li, Alexandar L. Hansen, and Rafael Brüschweiler. "COLMAR1d: A Web Server for Automated, Quantitative One-Dimensional Nuclear Magnetic Resonance-Based Metabolomics at Arbitrary Magnetic Fields." Analytical Chemistry (2024).

455) Singh, Rita, Sneh Bajpai, Amardeep Singh, Phulwanti Sharma, Yashwant Kumar, and Niraj Kumar. "Metabolomics of Chinese Hamster Ovary Cells." In Heterologous Protein Production in CHO Cells: Methods and Protocols, pp. 205-234. New York, NY: Springer US, 2024.

454) Qiu, Xu, and Xixiang Tang. "Metabolic adaptations of Shewanella eurypsychrophilus YLB-09 for survival in the high-pressure environment of the deep sea." Frontiers in Microbiology 15 (2024): 1467153.

453) Casarrubios Molina, Laura, Mónica Cicuéndez Maroto, Alberto Polo Montalvo, María José Feito Castellano, Álvaro Martínez Del Pozo, Daniel Arcos Navarrete, Iola F. Duarte, and María Teresa Portolés Pérez. "Metabolomic characterization of MC3T3-E1pre-osteoblast differentiation induced by ipriflavone-loaded mesoporous nanospheres." (2025).

452) de la Cabeza Fernández, María, Marta Sánchez, Laura Lozano-Chamizo, Ana Cristina Abreu, Ana Anguís-Morillas, Padreep K. Divakar, Marzia Marciello et al. "Electrospun nanofibers for localized drug release of a neuroprotective natural extract of USNEA ghattensis." European Journal of Pharmaceutics and Biopharmaceutics (2024): 114552.

451) Sahoo, Ashutosh, Deepanshu Verma, and Prajnadipta Panda. "A Gateway to Multi‐Omics‐Based Clinical Research." Applied Biotechnology and Bioinformatics: Agriculture, Pharmaceutical Research and Environment (2024): 235-256.

450) Hong, Natalie E., Alice Chaplin, Lin Di, Anastasia Ravodina, Graham H. Bevan, Huiyun Gao, Courteney Asase et al. "Nanoparticle-based itaconate treatment recapitulates low-cholesterol/low-fat diet-induced atherosclerotic plaque resolution." Cell Reports 43, no. 11 (2024).

449) Ruiz Coca, Mario, Cristian Perez-Fernandez, Ana Abreu, Ana Salmeron, Miguel Morales-Navas, Diego Ruiz-Sobremazas, Teresa Colomina, Ignacio Fernandez, and Fernando Sanchez-Santed. "Modulating Neurotoxic Effects of Prenatal Chlorpyrifos Exposure Through Probiotic and Vitamin D Gestational Supplementation: Unexpected Effects on Neurodevelopment and Sociability." bioRxiv (2024): 2024-11.

448) Artacho, Alejandro, Cintya González-Torres, Nuria Gómez-Cebrián, Paula Moles-Poveda, Javier Pons, Nuria Jiménez, María Jinglei Casanova et al. "Multimodal analysis identifies microbiome changes linked to stem cell transplantation-associated diseases." Microbiome 12, no. 1 (2024): 229.

447) Liu, Yongjian, Hao Liu, Shuqi Li, Shaojun Yu, and Heng Chen. "Synthesis of Harmaline N-9 Derivatives and Investigation of in Vitro Anticancer Activity."

446) Lima, Bruna R. de, Vanessa de Souza Marinho, Midori Nakamura Marques, Anne Caroline Gouvêa Ferreira, Edgar Aparecido Sanches, Jaqueline A. Bezerra, Pedro Henrique Campelo Felix, Jaime Paiva Lopes Aguiar, and Francisca Amaral Souza. "Influence of Thermosonication on Bioactive Compounds and Quality of Albertia Edulis Nectar." Available at SSRN 4998093 .

445) Saparuddin, Fatin, Mohd Naeem Mohd Nawi, Liyana Ahmad Zamri, Fazliana Mansor, Mohd Fairulnizal Md Noh, Mohd Azahadi Omar, Nur Shahida Abdul Aziz et al. "Metabolite, Biochemical, and Dietary Intake Alterations Associated with Lifestyle Interventions in Obese and Overweight Malaysian Women." Nutrients 16, no. 20 (2024): 3501.

444) Resendiz-Acevedo, Karen, Nuria Esturau-Escofet, Martha E. García-Aguilera, and Lena Ruiz-Azuara. "Casiopeinas®, CasIIIia and CasIIgly, Potent Anticancer Drugs and Their Metabolomic Effect in Triple-Negative Mesenchymal Breast Cancer. A Study by 1H-NMR." A Study by 1H-NMR.

443) Combe, Michelle, Kathy Sharon Isaac, Greg Potter, and Stanislav Sokolenko. "Current Research in Food Science." Current Research in Food Science 9 (2024): 100855.

442) Lu, Zhen, Na Gao, Junfei Zhan, Shuang Wang, Chenglong Ji, Li Zhang, and Huifeng Wu. "Comparative investigations on the metabolomic responses to cadmium in clams Ruditapes philippinarum from the Bohai Sea and South China Sea." Marine Pollution Bulletin 209 (2024): 117100.

441) Fresneda Alarcon, Michele, Yun Xu, Cassio Lima, Susanna Ford, Royston Goodacre, Marie Phelan, and Helen L. Wright. "Serum metabolomics identifies unique inflammatory signatures to distinguish rheumatoid arthritis responders and non-responders to TNF inhibitor therapy." medRxiv (2024): 2024-10.

440) Baud, Véronique, Leonardo Lordello, Stéphanie Nuan-Aliman, Karoline Kielbassa-Elkadi, Aurélie Montagne, Konstantina Kotta, Isabelle Martins et al. "Metabolic heterogeneity in DLBCL cells reveals an innovative antimetabolic combination strategy." (2024).

439) Trivedi, Rimjhim, Smita Singh, Vivek Singh, Sachin Yadav, Avinash Chandra Singh, Anup Singh, Rameshwar Nath Chaurasia, Abhai Kumar, and Dinesh Kumar. "Unravelling Neuroinflammation-Mediated Mitochondrial Dysfunction in Mild Cognitive Impairment: Insights from Targeted Metabolomics." Brain Organoid and Systems Neuroscience Journal.

438) Paudel, Devendra, Fuhua Hao, Umesh K. Goand, Sangshan Tian, Anthony M. Koehle, Loi V. Nguyen, Yuan Tian, Andrew D. Patterson, and Vishal Singh. "Elevated systemic total bile acids escalate susceptibility to alcohol-associated liver disease." iScience 27, no. 10 (2024).

437) Pudełko-Malik, Natalia, Dominika Drulis-Fajdasz, Łukasz Pruss, Karolina Anna Mielko-Niziałek, Dariusz Rakus, Agnieszka Gizak, and Piotr Młynarz. "A single dose of glycogen phosphorylase inhibitor improves cognitive functions of aged mice and affects the concentrations of metabolites in the brain." Scientific Reports 14, no. 1 (2024): 24123.

436) Imperlini, Esther, Federica Massaro, Angelica Grifoni, Francesco Maiurano, Anna Rita Taddei, Stefano Borocci, Francesco Buonocore, and Fernando Porcelli. "Membrane alteration, anti-virulence properties and metabolomic perturbation of a chionodracine-derived antimicrobial peptide, KHS-Cnd, on two bacteria models." Peptides (2024): 171311.

435) Chae, Young Kee, Hakbeom Kim, and Emine Sonay Elgin. "Discrimination of Turkish Propolis from Different Geographical Origins by NMR Spectroscopy." Journal of the Korean Magnetic Resonance Society 28, no. 3 (2024): 20-24.

434) Baud, Véronique, Thomas Becquard, Clara Benatar, Charles Bretot, Baptiste Eluard, Didier Bordereaux, Laura Thirouard et al. "The alternative NF-κB RelB subunit is a novel critical sensor of lipid metabolism to promote tumor development." (2024).

433) Bedulina, Daria, Špela Korez Lupše, Lars Hildebrandt, Yaqing Duan, Ole Klein, Sebastian Primpke, Christian Bock et al. "Effect of Particles from Wind Turbine Blades Erosion on Blue Mussels Mytilus Edulis." Available at SSRN 4882025.

432) Wojtowicz, Wojciech, R. Tarkowski, A. Olczak, A. Szymczycha-Madeja, P. Pohl, A. Maciejczyk, Ł. Trembecki, R. Matkowski, and Piotr Młynarz. "Serum metabolite and metal ions profiles for breast cancer screening." Scientific Reports 14, no. 1 (2024): 24559.

431) Johnson, Hayden Tyler. "Developing Accurate and Automated High-Field and Benchtop NMR-Based Metabolomic Techniques Using Neural Networks." PhD diss., The University of Memphis, 2024.

430) Amigó, N., L. Cabau, S. Iftimie, R. Pavón, X. Gavaldó, X. Correig, S. Paredes, J. C. Vallvé, and A. Castro. "Lipidomic and Metabolomic Changes in Community-acquired and COVID-19 Pneumonia."

429) Krebs, Nina. "The effect of acute warming on protein turnover and oxygen demand in stenothermal and eurythermal eelpouts." PhD diss., Universität Bremen, 2024.

428) Alves, Gabriel Machado. "Chemical characterization of sour beers with added fruits by hydrogen nuclear magnetic resonance." (2024).

427) Ερμείδης, Δημήτριος. "Ταυτοποίηση ενώσεων σε δείγματα ανθρωπίνων κοπράνων που σχετίζονται μ ε τη λήψη φλαβονοειδών." (2024).

426) Parenti, Mariana, Rebecca J. Schmidt, Daniel J. Tancredi, Irva Hertz-Picciotto, Cheryl K. Walker, and Carolyn M. Slupsky. "Network lOpen."

425) Castro, Alex, Antonio Gilberto Ferreira, Aparecida Maria Catai, Matheus Alejandro Bolina Amaral, Claudia Regina Cavaglieri, and Mara Patrícia Traina Chacon-Mikahil. "Metabolic Predictors of Cardiorespiratory Fitness Responsiveness to Continuous Endurance and High-Intensity Interval Training Programs: The TIMES Study—A Randomized Controlled Trial." Metabolites 14, no. 9 (2024): 512.

424) Fei, Shuangwen, Xiangrong Wang, Xinling Qin, Yaqian Yuan, Yujuan Zheng, Xue Lin, Jiamu Kang, Sixin Liu, and Congfa Li. "Efficient nata de coco production of Komagataeibacter nataicola driven by microbiota-fermented coconut water: biological and structural characteristics." Food Bioscience (2024): 105184.

423) Anzian, Aliaa, Muhaini Hussin, Rahman Qadir, Siti Hajar Azhari, Nurul Hanisah Juhari, Yus Aniza Yusof, Hazniza Adnan, and Anis Shobirin Meor Hussin. "Exploring the Physicochemical and Microbiological Properties of Glutinous Rice (Tapai pulut) Fermented using Lactobacillus plantarum: A Comprehensive Characterization using 1H-NMR." Food Bioscience (2024): 105165.

422) Naik, Arya R., Shreyada N. Save, Soumya S. Sahoo, Saurabh S. Yadav, Ashutosh Kumar, Jeetender Chugh, and Shilpy Sharma. "Metabolic Perturbations associated with hIAPP-induced insulin resistance in Skeletal Muscles: Implications to the Development of Type 2 Diabetes." The International Journal of Biochemistry & Cell Biology (2024): 106665.

421) Liu, Juan, Ariel Hanson, Wenzhen Yin, Qiao Wu, Eliane Wauthier, Jinmei Diao, Timothy Dinh et al. "Decellularized liver scaffolds for constructing drug-metabolically functional ex vivo human liver models." Bioactive Materials 43 (2025): 162-180.

420) Lv, Tianxing, Daojin Xue, Peng Wang, Wenxia Gong, and Kexin Wang. "Vanillic Acid Protects PC12 Cells from Corticosterone-Induced Neurotoxicity via Regulating Immune and Metabolic Dysregulation Based on Computational Metabolomics." ACS Omega (2024).

419) Spizzirri, Umile Gianfranco, Luigi Esposito, Paolino Caputo, Maria Martuscelli, Martina Gaglianò, Maria Lisa Clodoveo, Giuseppina De Luca et al. "Carob pulp flour as an innovative source of bioactive molecules for the preparation of high-value-added jellies." Heliyon (2024).

418) Yuan, Xiao-Fang, Hong Zhong, Zhao-Ying Xiao, Zhan-Jun Lu, Wei Chen, Ying-Xue Liu, Gu-Chun Zhou, Xiao-Qiang Liu, Ming-Jie Deng, and Hai-Zhong Yu. "Integrated transcriptome and 1H NMR-based metabolome to explore the potential mechanism of Spodoptera litura in response to flupyrimin." Pesticide Biochemistry and Physiology (2024): 106146.

417) Kim, Hyun-Jun, Hye-Jin Kim, and Cheorun Jo. "Exploring the modulation of extracellular metabolites in different Listeria monocytogenes strains under cold-stress." Food Science of Animal Resources (2024).

416) Lawson, Melissa AE, Matthew Dalby, Shabhonam Caim, Larissa Richardson, Albert Koulman, Raymond Kiu, Gwenaelle Le Gall, and Lindsay J. Hall. "Early life milk diets shape infant gut microbiota: evidence of microbial plasticity in response to breast and formula milk." bioRxiv (2024): 2024-09.

415) Kanokruangrong, Siripong, Biniam Kebede, Alan Carne, Ian Stewart, and Alaa El-Din A. Bekhit. "Metabolomic investigation of fresh beef, lamb and venison using nuclear magnetic resonance spectroscopy in relation to colour stability." Food Chemistry (2024): 141447.

414) Ketheeswaranathan, Bianka. "Impacts of Dietary Fibre-derived Metabolites on Inflammation and Neurodevelopment." PhD diss., University of Guelph, 2024.

413) Yang, Qianlu. "Acidic ascites inhibits gastric and ovarian cancer cell proliferation and correlate with the metabolomic, lipidomic, and inflammatory phenotype of human patients." PhD diss., Universität Tübingen, 2024.

412) Lv, Jun-li, Wen-qing Lai, Lei Pang, Xiao-ying Zhang, Kai-yi Zheng, Qiang Zhang, Zhan-peng Lu et al. "Mode of action underlying toxicity of Camptothecin to Spodoptera frugiperda (Lepidoptera) larvae." Journal of Asia-Pacific Entomology (2024): 102322.

411) Nascimento, Maria Beatriz Augusto do. "Food consumption, metabolomic profile and energy production pathways of female soccer athletes." (2024).

410) Fei, Shuangwen, Xiangrong Wang, Xinling Qin, Yaqian Yuan, Yujuan Zheng, Xue Lin, Jiamu Kang, Sixin Liu, and Congfa Li. "Efficient nata de coco production of Komagataeibacter nataicola driven by microbiota-fermented coconut water: biological and structural characteristics." Food Bioscience (2024): 105184.

409) Petrella, Greta, Camilla Montesano, Sara Lentini, Giorgia Ciufolini, Domitilla Vanni, Roberto Speziale, Andrea Salonia et al. "Personalized metabolic pro le by synergic use of NMR and HRMS."

408) Fresneda Alarcon, Michele. "Metabolic regulation of human neutrophils in rheumatoid arthritis." PhD diss., University of Liverpool, 2024.

407) Nascimento, Maria Beatriz Augusto do. "Food consumption, metabolomic profile and energy production pathways of female soccer athletes." (2024).

406) Cochran, Darcy, Panteleimon G. Takis, James L. Alexander, Benjamin H. Mullish, Nick Powell, Julian Marchesi, and Robert Powers. "Evaluating Protocols for Reproducible Targeted Metabolomics by NMR." Analyst (2024).

405) Kostidis, Sarantos. "NMR-Based Analysis of Cellular Central Energy Metabolism and Exchange Rates." In Clinical Metabolomics: Methods and Protocols, pp. 505-519. New York, NY: Springer US, 2024.

404) Srivastava, Shatakshi, and Moin Uddin. "Recent trends in metabolomics, machine learning and artificial intelligence." In Artificial Intelligence in Biomedical and Modern Healthcare Informatics, pp. 91-100. Academic Press, 2025.

403) Tabago, Maria Krizel Anne G., Mark Christian Emmanuel A. Marmeto, George D. Posadas, Anna Karen C. Laserna, and Joel Garcia. "Multi-platform metabolic profiling of the stages of production of locally made lambanog, a traditional Philippine alcoholic beverage." Discover Chemistry 1, no. 1 (2024): 32.

402) Šimunić, Ena, Iva I. Podgorski, Marija Pinterić, Marijana Popović Hadžija, Robert Belužić, Mladen Paradžik, Lucija Dončević et al. "Sirtuin 3 drives sex-specific responses to age-related changes in mouse embryonic fibroblasts." Mechanisms of Ageing and Development (2024): 111996.

401) Lawson, Ariel, Mark Annunziato, Narmin Bashirova, Muhamed N. Hashem Eeza, Jörg Matysik, A. Alia, and John P. Berry. "High-Resolution Magic-Angle Spinning Nuclear Magnetic Resonance Identifies Impairment of Metabolism by T-2 Toxin, in Relation to Toxicity, in Zebrafish Embryo Model." Toxins 16, no. 10 (2024): 424.

400) Millar, Molly E., Miriam Abele, Hannah C. Harris, Todor T. Koev, Andrea Telatin, Raymond Kiu, Douwe Van Sinderen et al. "Novel amylase genes enable utilisation of resistant starch by bifidobacteria relevant to early-life microbiome development." bioRxiv (2024): 2024-10.

399) Skorupa, Agnieszka, Mateusz Klimek, Mateusz Ciszek, Sławomir Pakuło, Tomasz Cichoń, Bartosz Cichoń, Łukasz Boguszewicz, Andrzej Witek, and Maria Sokół. "Metabolomic Analysis of Histological Composition Variability of High-Grade Serous Ovarian Cancer Using 1H HR MAS NMR Spectroscopy." International Journal of Molecular Sciences 25, no. 20 (2024): 10903.

398) Lin, Penghui, Andrew N. Lane, and Teresa W-M. Fan. "NMR-based stable isotope tracing of cancer metabolism." In Clinical Metabolomics: Methods and Protocols, pp. 457-504. New York, NY: Springer US, 2024.

397) Mamede, Lucia. "Metabolomic Investigation of Natural Antiplasmodial Agents." PhD diss., Universite de Liege (Belgium), 2024.

396) Ko, Joungbo, Choongsung Yoo, Dante Xing, Jisun Chun, Drew E. Gonzalez, Broderick L. Dickerson, Megan Leonard et al. "Effects of Human Milk Oligosaccharide 2′-Fucosyllactose Ingestion on Weight Loss and Markers of Health." Nutrients 16, no. 19 (2024): 3387.

395) Zhao, Xiaorui, Weiwei He, Louise Margrethe Arildsen Jakobsen, Farhad Panah, Banny Correia, Dennis Sandris Sandris Nielsen, Axel K. Hansen, and Hanne Christine Bertram. "Influence of dairy matrix on the prebiotic effects of inulin related to gut metabolic activity and bone health." Food & Function (2024).

394) Albacarys, Lauren, Moataz M. Gadalla, Mario Amzel, Peixin Yang, and Solomon H. Snyder. "Mammalian D-Cysteine controls insulin secretion in the pancreas." (2024).

393) Arianna, Cirillo. "Application of Metabolomics to the Evaluation of Renal Function in Kidney Transplantation." PhD diss., Universite de Liege (Belgium), 2024.

392) Sorge, Sebastian, Victor Girard, Lena Lampe, Vanessa Tixier, Alexandra Weaver, Theresa Higgins, and Alex P. Gould. "A Drosophila holidic diet optimised for growth and development." bioRxiv (2024): 2024-09.

391) Kiy, Robyn. "Investigating potential mitochondrial mechanisms of, and understanding the effect of mitochondrial genome on, antimicrobial-induced liver injury." PhD diss., University of Liverpool, 2024.

390) Abi Assaf, Justin, Jean-Charles de Coriolis, Alice May Godden, Eve Redhead, Jamie Bartram, Jayme Cohen-Krais, Karina Silova et al. "Gum Arabic (Acacia senegal) enhances reproduction and modulates the microbiota-gut-brain axis of zebrafish in a sex-specific and dosage-dependent manner." bioRxiv (2024): 2024-10.

389) GILLSON, JOSEF. "Development of Novel Therapy Targeting Autophagy Against Advanced and Chemo-resistant Pancreatic Cancer." PhD diss., Faculty of Medicine & Health, The University of Sydney, 2024.

388) Carneiro, Tatiana João Ribeiro Gonçalves. "Biomarcadores Metabólicos de Eficácia de Cisplatina e de um Potencial Novo Fármaco de Paládio no Cancro da Mama Triplo-Negativo." PhD diss., Universidade de Aveiro (Portugal), 2024.

387) Colombera, Maiara Caroline. "Evaluation of leucine supplementation on the effects of tumor factors in H9c2 cardiac muscle cells." PhD diss., [sn], 2024.

386) Nichols, Robert G., Bipin Rimal, Fuhua Hao, Jeffrey M. Peters, Emily R. Davenport, and Andrew D. Patterson. "Chlorpyrifos modulates the mouse gut microbiota and metabolic activity." Environment International (2024): 109022.

385) Combe, Michelle, Kathy Sharon Isaac, Greg Potter, and Stanislav Sokolenko. "NMR Metabolomics of Plant and Yeast-based Hydrolysates for Cell Culture Media Applications—A Comprehensive Assessment." Current Research in Food Science (2024): 100855.

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168) Santamaria, Guillem, and Francisco R. Pinto. "Bioinformatic Analysis of Metabolomic Data: From Raw Spectra to Biological Insight." BioChem 4, no. 2 (2024): 90-114.

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158) Su, Congyan, Ming Yang, Shuai Chen, Chuanxian Fu, Lin Zhang, Sixin Liu, Jiamu Kang, and Congfa Li. "Multiple metabolite profiles uncover remarkable bioactive compounds and metabolic characteristics of noni fruit (Morinda citrifolia L.) at various stages of ripeness." Food Chemistry (2024): 139357.

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152) Madhav, Rahul, and Rabmit Das. "Machine Learning Approach for Metabolite Profiling in Complex Mixtures via NMR Data."

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147) Kim, Nam-Hee, Hye Sun Choi, Moon Young Lee, Hyunbin Seong, Nam Soo Han, Hae-Jin Hu, Yong Sung Kim, and Jung Ho Park. "The Effects of Fermented Rice Drink With Lactiplantibacillus plantarum JSA22 in Overweight Irritable Bowel Syndrome Patients: A Randomized, Double-blind, Placebo-controlled Study." Journal of Neurogastroenterology and Motility 30, no. 2 (2024): 194-207.

146) Gautam, Vedant, Ravi Nagar, Pradeep Barai, Vibhootee Garg, Shreyashi Singh, Himanshu Singh, Shubham Patel, Ashish Kumar, and R. K. Singh. "Exploring the Rice Root Metabolome to Unveil the Key Biomarkers Under the Stress of Meloidogyne Graminicola."

145) Madhav, Rahul, and Rabmit Das. "Machine Learning Approach for Metabolite Profiling in Complex Mixtures via NMR Data."

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141) Forde, Braxton, Samuel Martin, Miki Watanabe-Chailland, and Foong-Yen Lim. "Acute Fetal Metabolomic Changes in Twins Undergoing Fetoscopic Surgery for Twin-Twin Transfusion Syndrome." Twin Research and Human Genetics (2024): 1-8.

140) Laue, Hannah E., Julia A. Bauer, Wimal Pathmasiri, Susan CJ Sumner, Susan McRitchie, Thomas J. Palys, Anne G. Hoen, Juliette C. Madan, and Margaret R. Karagas. "Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers." Pediatric Research (2024): 1-8.

139) Thaiwatcharamas, Kanokrat, Watcharin Loilome, Phuc N. Ho, Sinobol Chusilp, Patchareeporn Tanming, Poramate Klanrit, and Jutarop Phetcharaburanin. "Children with Hirschsprung disease exhibited alterations in host–microbial co-metabolism after pull-through operation." Pediatric Surgery International 40, no. 1 (2024): 1-10.

138) Mascellani Bergo, Anna, Kirsten Leiss, and Jaroslav Havlik. "Twenty Years of 1H NMR Plant Metabolomics: A Way Forward toward Assessment of Plant Metabolites for Constitutive and Inducible Defenses to Biotic Stress." Journal of Agricultural and Food Chemistry (2024).

137) Condori, Luis Daniel Montañez, Cristofher Victor Vivas, Yan Borges Barreto, Ligia Ferreira Gomes, Adriano Mesquita Alencar, and Antonio Carlos Bloise. "Effects of Hypoxia and Reoxygenation on Metabolic Profiles of Cardiomyocytes." Cell Biochemistry and Biophysics (2024): 1-17.

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134) Hecht, Aaron L., Lisa C. Harling, Elliot S. Friedman, Ceylan Tanes, Junhee Lee, Jenni Firrman, Fuhua Hao et al. "Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae." The Journal of Clinical Investigation (2024).

133) Gao, Huanting, Dongxiao Li, Haiyan Hu, Feng Zhou, Yongang Yu, Qichao Wei, Qili Liu et al. "Regulation of carbohydrate metabolism during anther development in a thermo‐sensitive genic male‐sterile wheat line." Plant, Cell & Environment.

132) Ruud, Linda Engström, Ferran Font-Gironès, Joanna Zajdel, Lara Kern, Júlia Teixidor-Deulofeu, Louise Mannerås-Holm, Alba Carreras et al. "Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor." Cell Reports 43, no. 4 (2024).

131) Azmi, Adiez Sapura, Amerul Afiq Aspa, Muhammad Adam Azidi, Hazarul Izham Roszaiman, Ahmed Mediani, Juliana Yusoff, and Fatimah Salim. "1H-NMR Based Chemometric Approach for Phytochemicals Variation Study on Erythrina fusca Flower Extracts and Correlation with Their Antibacterial Activity."

130) Zolkeflee, Nur Khaleeda Zulaikha, Pei Lou Wong, M. Maulidiani, Nurul Shazini Ramli, Azrina Azlan, Ahmed Mediani, Chau Ling Tham, and Faridah Abas. "Revealing metabolic and biochemical variations via 1H NMR metabolomics in streptozotocin-nicotinamide-induced diabetic rats treated with metformin." Biochemical and Biophysical Research Communications (2024): 149778.

129) Gouveia, Goncalo Jorge, Thomas Head, Leo L. Cheng, Chaevien S. Clendinen, John R. Cort, Xiuxia Du, Arthur S. Edison et al. "Perspective: use and reuse of NMR-based metabolomics data: what works and what remains challenging." Metabolomics 20, no. 2 (2024): 1-11.

128) Drevet Mulard, Eva, Sylvie Guibert, Anne Mey, Camille Lefevre, Marie-Agnès Chauvin, Claudie Pinteur, Marie-Ambre Monet et al. "A Cross-Sectional Quantitative Metabolomics Study Evidencing the Metabolic Signature in Six Organs during a 14-Week High-Fat High-Sucrose and Standard Diet in Mice." Nutrients 16, no. 6 (2024): 803.

127) Yousf, Saleem, Hitender S. Batra, Rakesh M. Jha, Devika M. Sardesai, Kalyani Ananthamohan, Jeetender Chugh, and Shilpy Sharma. "Identification of potential serum biomarkers associated with HbA1c levels in Indian type 2 diabetic subjects using NMR-based metabolomics." Clinica Chimica Acta (2024): 117857.

126) Hoa, Van Ba, Dong-Gyun Kim, Dong-Heon Song, Ji-Hun Ko, Hyun-Wook Kim, In-Seon Bae, Yun-Seok Kim, and Soo-Hyun Cho. "Quality properties and flavor-related components of beef longissimus lumborum muscle from four Korean native cattle breeds." Food Science of Animal Resources (2024).

125) Ma, Bangguo, Xiaoli Zhao, Xiaoning Zhang, Bowen Yang, Zimin Cai, Zihan Xing, Mingzhe Xu et al. "The acute neurotoxicity of inorganic mercury in Mactra chinensis philippi." Aquatic Toxicology (2024): 106896.

124) Cirillo, A., M. Vandermeulen, P. Erpicum, T. Pinto Coelho, N. Meurisse, O. Detry, F. Jouret, and P. de Tullio. "Untargeted NMR-based metabolomics analysis of kidney allograft perfusates identifies a signature of delayed graft function." Metabolomics 20, no. 2 (2024): 39.

123) Xie, Zhuqing, Weiwei He, Alex Gobbi, Hanne Christine Bertram, and Dennis Sandris Nielsen. "The effect of in vitro simulated colonic pH gradients on microbial activity and metabolite production using common prebiotics as substrates." BMC Microbiology 24, no. 1 (2024): 83.

122) Astono, Julie, Katrine O. Poulsen, Rikke A. Larsen, Emma V. Jessen, Chatrine B. Sand, Morten A. Rasmussen, and Ulrik K. Sundekilde. "Metabolic maturation in the infant urine during the first 3 months of life." Scientific Reports 14, no. 1 (2024): 5697.

121) Colì, Chiara Stella, Chiara Roberta Girelli, Gianluigi Cesari, Mudassar Hussain, and Francesco Paolo Fanizzi. "Biodynamic, organic and integrated agriculture effects on cv. Italia table grapes juice, over a 3-year period experiment: an 1H NMR spectroscopy-based metabolomics study." Chemical and Biological Technologies in Agriculture 11, no. 1 (2024): 1-17.

120) Tan, Dai Chuan, Nur Kartinee Kassim, Intan Safinar Ismail, and Siok Geok Chong. "Identification of dipeptidyl peptidase-4 inhibitory compounds of Paederia foetida twigs by nuclear magnetic resonance metabolomics, in silico models, and liquid chromatography–mass spectrometry profiling." The Thai Journal of Pharmaceutical Sciences 47, no. 3 (2024): 4.

119) Paul, Michael St, Samuel D. Saibil, Meghan Kates, SeongJun Han, Scott C. Lien, Rob C. Laister, Kebria Hezaveh et al. "Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy." Cell Reports Medicine (2024).

118) Chen, Jie, Shuting Wang, Fuchuan Guo, Yupeng Gong, Tianbao Chen, Chris Shaw, Rencai Jiang, Fang Huang, and Dai Lin. "1H‐NMR‐based metabolomics reveals the preventive effect of Enteromorpha prolifera polysaccharides on diabetes in Zucker diabetic fatty rats." Food Science & Nutrition (2024).

117) Lucio-Gutiérrez, Juan Ricardo, Paula Cordero-Pérez, José Luis Ávila-Velázquez, Liliana Torres-González, Iris Farías-Navarro, Gustavo Govea-Torres, Concepción Sánchez-Martínez et al. "Targeted and Untargeted Serum NMR Metabolomics to Reveal Initial Kidney Disease in Diabetes Mellitus." Available at SSRN 4743664.

116) Colosimo, Raffaele, Hannah C. Harris, Jennifer Ahn-Jarvis, Perla Troncoso-Rey, Tim JA Finnigan, Pete J. Wilde, and Frederick J. Warren. "Colonic in vitro fermentation of mycoprotein promotes shifts in gut microbiota, with enrichment of Bacteroides species." Communications Biology 7, no. 1 (2024): 272.

115) Park, Gwoncheol, Saurabh Kadyan, Nathaniel Hochuli, Julie Pollak, Bo Wang, Gloria Salazar, Paramita Chakrabarty, Philip Efron, Julia Sheffler, and Ravinder Nagpal. "A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms." Gut Microbes 16, no. 1 (2024): 2323752.

114) Winkvist, Anna, Ingegerd Johansson, Lars Ellegård, and Helen M. Lindqvist. "Towards objective measurements of habitual dietary intake patterns: comparing NMR metabolomics and food frequency questionnaire data in a population-based cohort." Nutrition Journal 23, no. 1 (2024): 1-12.

113) Bhinderwala, Fatema, Heidi E. Roth, Mary Filipi, Samantha Jack, and Robert Powers. "Potential Metabolite Biomarkers of Multiple Sclerosis from Multiple Biofluids." ACS Chemical Neuroscience (2024).

112) Dhamija, Bhavuk, Soumitra Marathe, Vinanti Sawant, Moumita Basu, Diksha Attrish, Ditipriya Mukherjee, Sushant Kumar et al. "IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated Metabolic Reprogramming in Psoriasis." The Journal of Immunology (2024).

111) Tomisova, Katerina, Veronika Jarosova, Petr Marsik, Anna Mascellani Bergo, Ondrej Cinek, Lucie Hlinakova, Pavel Kloucek, Vaclav Janousek, Kateřina Valentová, and Jaroslav Havlik. "The Mutual Interactions of Silymarin and Colon Microbiota from Healthy Young and Healthy Elder Subjects." (2024).

110) Jumpa, Thitiwan, Jutarop Phetcharaburanin, Manida Suksawat, Kunlaya Pattanagul, and Wattana Pattanagul. "AJAB." Asian J Agric & Biol 1 (2024).

109) Serrano‐Contreras, Jose Ivan, John C. Lindon, Gary Frost, Elaine Holmes, Jeremy K. Nicholson, and Isabel Garcia‐Perez. "Implementation of pure shift 1H NMR in metabolic phenotyping for structural information recovery of biofluid metabolites with complex spin systems." NMR in Biomedicine 37, no. 3 (2024): e5060.

108) Verhoeven, Aswin, Rico J. Derks, and Martin Giera. "NMR-Based Metabolomics: Monitoring Metabolic Response to Physical Exercise." In A Practical Guide to Metabolomics Applications in Health and Disease: From Samples to Insights into Metabolism, pp. 235-270. Cham: Springer International Publishing, 2024.

107) Murray, Breanne A., and Karen L. Machin. "Utilizing NMR fecal metabolomics as a novel technique for detecting the physiological effects of food shortages in waterfowl." Frontiers in Physiology 14 (2024): 1229152.

106) Souza, Peter Gabriel Almeida, Jaqueline do Carmo Lima Carvalho, Lorrana Zelia Martins de Souza, Evaneide Nascimento Lima, Mariana Guerra de Aguilar, Robson Pereira Lima, Osania Emerenciano Ferreira, Lúcia Pinheiro Santos Pimenta, and Alan Rodrigues Teixeira Machado. "Effect of Pyrolysis Temperature on the Production of Biochar and Biomethanol from Sugarcane Bagasse." BioEnergy Research (2024): 1-8.

105) Pariyani, Raghunath, Yumei Zhang, Gudmundur G. Haraldsson, Kang Chen, Kaisa M. Linderborg, and Baoru Yang. "Metabolomic Investigation of Brain and Liver in Rats Fed Docosahexaenoic Acid in Regio‐and Enantiopure Triacylglycerols." Molecular Nutrition & Food Research (2024): 2300341.

104) Fall, Fanta, Lucia Mamede, Madeline Vast, Pascal De Tullio, Marie-Pierre Hayette, Paul AM Michels, Michel Frédérich, Bernadette Govaerts, and Joëlle Quetin-Leclercq. "First comprehensive untargeted metabolomics study of suramin-treated Trypanosoma brucei: an integrated data analysis workflow from multifactor data modelling to functional analysis." Metabolomics 20, no. 2 (2024): 1-17.

103) Ellisor, Debra L., Amanda L. Bayless, Tracey B. Schock, W. Clay Davis, B. Trey Knott, John Seghers, Hanne Leys, and Håkan Emteborg. "Multi-omics characterization of NIST seafood reference materials and alternative matrix preparations." Analytical and Bioanalytical Chemistry 416, no. 3 (2024): 773-785.

102) Liu, Wen-Ya, Xin Feng, and Jun-Song Wang. "Total cucurbitacins from Herpetospermum pedunculosum pericarp do better than Hu-lu-su-pian (HLSP) in its safety and hepatoprotective efficacy." Frontiers in Pharmacology 15 (2024): 1344983.

101) Palande, Aseem, Saniya Patil, Anjali Veeram, Soumya Swastik Sahoo, Tejan Lodhiya, Pankaj Maurya, Balaji Muralikrishnan, Jeetender Chugh, and Raju Mukherjee. "Proteomic Analysis of the Mycobacterium tuberculosis Outer Membrane for Potential Implications in Uptake of Small Molecules." ACS Infectious Diseases (2024).

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648) Alexandersson, Elin, Corine Sandström, Johan Meijer, Gustav Nestor, Anders Broberg, and Hanna E. Röhnisch. "Extended automated quantification algorithm (AQuA) for targeted 1H NMR metabolomics of highly complex samples: application to plant root exudates." Metabolomics 20, no. 1 (2023): 11.

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635) WONG, Pei Lou, Nurul Shazini RAMLI, Chin Ping TAN, Azrina AZLAN, and A. B. A. S. Faridah. "NMR-based metabolomics and UHPLC-ESI-MS/MS profiling of Syzygium jambos in relation to their antioxidant and anti-hyperglycemic activities." Arabian Journal of Chemistry (2023): 105546.

634) Bloch, Sylwia, Natalia Lewandowska, Joanna Zwolenkiewicz, Paulina Mach, Aleksandra Łukasiak, Mikołaj Olejniczak, Logan W. Donaldson, Grzegorz Węgrzyn, and Bożena Nejman-Faleńczyk. "Bacteriophage-encoded 24B_1 molecule resembles herpesviral microRNAs and plays a crucial role in the development of both the virus and its host." Plos one 18, no. 12 (2023): e0296038.

633) Jedal, Jonathan YB, Anders Malmendal, and Hans Ramløv. "METABOLITES, IONS, AND THE MECHANISMS BEHIND SEASONAL COLD HARDENING OF PYROCHROA COCCINEA (PYROCHROIDAE) LARVAE." Journal of Insect Physiology (2023): 104610.

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631) Boguszewicz, Łukasz, Agata Bieleń, Mateusz Ciszek, Agnieszka Skorupa, Jolanta Mrochem-Kwarciak, Krzysztof Składowski, and Maria Sokół. "Metabolomic Insight into Implications of Induction Chemotherapy Followed by Concomitant Chemoradiotherapy in Locally Advanced Head and Neck Cancer." International Journal of Molecular Sciences 25, no. 1 (2023): 188.

630) Onat-Taşdelen, Kadriye Aslıhan, Hatice Öztürkel-Kabakaş, Ecem Yüksektepe, Şükrü Serter Çatav, Gülnur Güzel, Bekir Çöl, Hakbeom Kim, Young Kee Chae, and Emine Sonay Elgin. "Functional groups matter: metabolomics analysis of Escherichia coli exposed to trans-cinnamic acid and its derivatives unveils common and unique targets." World Journal of Microbiology and Biotechnology 40, no. 2 (2024): 47.

629) Charris-Molina, Andrés, Paula Burdisso, and Pablo A. Hoijemberg. "Multiplet-Assisted Peak Alignment for 1H NMR-Based Metabolomics." Journal of Proteome Research (2023).

628) Oliveira, Márcio Felipe, Moacir Cavalcante de Albuquerque Neto, Thiago Siqueira Leite, Paulo André Araújo Alves, Salvador Vilar Correia Lima, and Ricardo Oliveira Silva. "Performance evaluate of different chemometrics formalisms used for prostate cancer diagnosis by NMR-based metabolomics." Metabolomics 20, no. 1 (2023): 8.

627) Rodrigues, Barbara Martins, Ramon Costa Alvarenga, Dante Pazzanese Duarte Lanna, Afonso de Liguori Oliveira, Caroline Ceribeli, Banny Silva Barbosa Correia, Luiz Alberto Colnago, Daniel Rodrigues Cardoso, Fernando Antônio de Souza, and Leandro Sâmia Lopes. "Aged-beef quality and fatty acid profile of subcutaneous fat from Nellore and Nellore× Angus crossbred young bulls finished in the feedlot with a high-lipid diet." Animal Production Science (2023).

626) Sanchez-Rodriguez, Laura, Marta Galvez-Fernandez, Ayelén Rojas-Benedicto, Arce Domingo-Relloso, Nuria Amigo, Josep Redon, Daniel Monleon et al. "Traffic Density Exposure, Oxidative Stress Biomarkers and Plasma Metabolomics in a Population-Based Sample: The Hortega Study." Antioxidants 12, no. 12 (2023): 2122.

625) Gulati, Khushboo, Radhika Manukonda, Manikyaprabhu Kairamkonda, Swathi Kaliki, and Krishna Mohan Poluri. "Serum Metabolomics of Retinoblastoma: Assessing the Differential Serum Metabolic Signatures of Unilateral and Bilateral Patients." ACS omega (2023).

624) Yilmaz, Ali, Sigal Liraz-Zaltsman, Esther Shohami, Juozas Gordevičius, Ieva Kerševičiūtė, Eric Sherman, Ray O. Bahado-Singh, and Stewart F. Graham. "The longitudinal biochemical profiling of TBI in a drop weight model of TBI." Scientific reports 13, no. 1 (2023): 22260.

623) Johnsen, Philip. "Application of Environmental Metabolomics for Assessment of Aquatic Invertebrate Sensitivity to Naphthenic Acids." Master's thesis, University of Waterloo, 2023.

622) Lan, Wenning, Xiaolian Xiao, Xiaojing Zhang, Jingjing Nian, Ziran Wang, Yajiao Wu, Dongcheng Zhang et al. "Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism." bioRxiv (2023): 2023-12.

621) Yadav, Sachin, Abhai Kumar, Smita Singh, Shahnawaz Ahmad, Gurvinder Singh, Abdul Rahman Khan, Rameshwar Nath Chaurasia, and Dinesh Kumar. "NMR based Serum metabolomics revealed metabolic signatures associated with oxidative stress and mitochondrial damage in brain stroke." Metabolic Brain Disease (2023): 1-12.

620) Ducros, Loïck, Mohamed Touaibia, Nicolas Pichaud, and Simon G. Lamarre. "Resilience and phenotypic plasticity of Arctic char (Salvelinus alpinus) facing cyclic hypoxia: insights into growth, energy stores and hepatic metabolism." Conservation Physiology 11, no. 1 (2023): coad099.

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618) Rodrigues, João A., Evla Ferro, Rita Araújo, Ana V. Henriques, Ana M. Gomes, Marta W. Vasconcelos, and Ana M. Gil. "Metabolic Evaluation of Lupin-Enriched Yogurt by Nuclear Magnetic Resonance Metabolomics." Journal of Agricultural and Food Chemistry (2023).

617) Domżał, Barbara, Ewa Klaudia Nawrocka, Dariusz Gołowicz, Michał Aleksander Ciach, Błażej Miasojedow, Krzysztof Kazimierczuk, and Anna Gambin. "Magnetstein: An Open-Source Tool for Quantitative NMR Mixture Analysis Robust to Low Resolution, Distorted Lineshapes, and Peak Shifts." Analytical Chemistry (2023).

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615) Di Nisio, Andrea, Luca De Toni, Iva Sabovic, Alessia Vignoli, Leonardo Tenori, Stefano Dall’Acqua, Stefania Sut et al. "Lipidomic Profile of Human Sperm Membrane Identifies a Clustering of Lipids Associated with Semen Quality and Function." International Journal of Molecular Sciences 25, no. 1 (2023): 297.

614) Litzenberg, Kerryanne Lenore. "The Physiological Effects of Age and Temperature on Blood Chemistry, Metabolism, and Mortality of Harvested Horseshoe Crabs (Limulus polyphemus)." PhD diss., College of Charleston, 2023.

613) Hernandez-Baixauli, Julia, Gertruda Chomiciute, Juan María Alcaide-Hidalgo, Anna Crescenti, Laura Baselga-Escudero, Hector Palacios-Jordan, Elisabet Foguet-Romero et al. "Developing a model to predict the early risk of hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL): a translational study." Scientific Reports 13, no. 1 (2023): 22646.

612) Zizmare, Laimdota. "Common Metabolites, Distinct Pathways: The Use of High-field NMR Spectroscopy Metabolomics in Neurology and Immunology." PhD diss., Universität Tübingen, 2023.

611) Wu, Jinxia, Zhenchang Li, Hongwei Zhu, Yajie Chang, Quanquan Li, Jing Chen, Guiping Shen, and Jianghua Feng. "Childhood overweight and obesity: age stratification contributes to the differences in metabolic characteristics." Obesity (2023).

610) Bruzzone, Chiara. "NMR-based metabolomics in precision medicine. Application to metabolic syndrome and COVID-19." (2023).

609) Tokarska-Schlattner, Malgorzata, Nour Zeaiter, Valerie Cunin, Stephane Attia, Cecile Meunier, Laurence Kay, Amel Achouri et al. "Multi-method quantification of acetyl-CoA and further acyl-CoA species in normal and ischemic rat liver." bioRxiv (2023): 2023-09.

608) Gentile, Antonio, Andrea Fulgione, Barbara Auzino, Valentina Iovane, Daniela Gallo, Raffaele Garramone, Nunzia Iaccarino et al. "The Evolution of TLR4: In-Silico and Research Model in Mediterranean Water Buffalo."

607) Van Bakel, Wouter. "Molecular mechanisms underpinning host O-glycan metabolism by human gut symbionts." PhD diss., University of East Anglia, 2023.

606) Cabral, Vitor, Rita A. Oliveira, Margarida B. Correia, Miguel F. Pedro, Carles Ubeda, and Karina B. Xavier. "Gut protective Klebsiella species promotes microbiota recovery and pathobiont clearance while preventing inflammation." bioRxiv (2023): 2023-11.

605) Di Risola, Daniel. "Use of olive oil polyphenols to counteract neuroinflammation and neurodegenerative diseases." (2023).

604) Khanijou, Jasmeet Kaur, Yan Ting Hee, and Kumar Selvarajoo. "Check for updates Chapter." Systems Biology 2745 (2024): 1.

603) González Torres, Luis Andrés. "Characterization of the serum metabolomic profile of patients with grades III and IV hepatic encephalopathy." PhD diss., Autonomous University of Nuevo León, 2023.

602) García Baeza, Antoni. "Metabolomics-derived insights into the metabolic regulation and control of centellosides in hairy root cultures of Centella asiatica." PhD diss., Autonomous University of Nuevo León, 2023.

601) Fresneda Alarcon, Michele, Genna Ali Abdullah, Andrew H. Nolan, Christina Linford, Marie M. Phelan, and Helen L. Wright. "PFKFB3 is a critical regulator of neutrophil metabolism and function in rheumatoid arthritis." medRxiv (2023): 2023-12.

600) 宋子豪. "Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis." PhD diss., 北海道大学, 2023.

599) Lee, Dongheon, Hyun Jung Lee, Ki-Chang Nam, Doo Yeon Jung, Ji Won Kim, Jong Hyun Jung, Sung-Sil Moon, and Cheorun Jo. "Metabolomic Approach to Understand the Effect of Lairage on the Quality of Pork Loin." Meat and Muscle Biology 7, no. 1 (2023).

598) Govindasamy, Chandramohan, Khalid S. Al-Numair, Mohammed A. Alsaif, Abilash Valsala Gopalakrishnan, and Raja Ganesan. "Assessment of metabolic responses following silica nanoparticles in zebrafish models using 1H NMR analysis." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology (2023): 109808.

597) Carneiro, Tatiana J., Ana LM Carvalho, Martin Vojtek, Inês F. Carmo, Maria Paula M. Marques, Carmen Diniz, and Ana M. Gil. "Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics." Cancer Cell International 23, no. 1 (2023): 1-17.

596) Nord, Anders Bay, Helen Lindqvist, Millie Rådjursöga, Anna Winkvist, Göran Karlsson, and Daniel Malmodin. "Experimental design of blending samples to increase precision of 1H NMR urine metabolomics." (2023).

595) Hurtado, Joaquín I., Andrés López-Radcenco, José Luis Izquierdo-García, Fernando Rodríguez, Guillermo Moyna, Gonzalo Greif, and Nicolas Nin. "A comparative NMR-based metabolomics study of lung parenchyma of severe COVID-19 patients." Frontiers in Molecular Biosciences 10 (2023).

594) Tomczyk, Mateusz. "Investigating the role of SIRT3 in doxorubicin induced dilated cardiomyopathy." (2023).

593) Netrprachit, Papichaya, Nitra Nuangchamnong, Nurul Shazini Ramli, Maulidiani Maulidiani, Ahmed Mediani, Nur Khaleeda Zulaikha Zolkeflee, Sudarat Jiamyangyuen, and Faridah Abas. "Bioactive compounds of pigmented rice extracts reveal by NMR-based metabolomics." CyTA-Journal of Food 21, no. 1 (2023): 760-770.

592) Praveen, Kuppan, Sudharsanam Abinandan, Kadiyala Venkateswarlu, and Mallavarapu Megharaj. "Harnessing Extremophilic Trait and Metabolic Flexibility of Microalgal Strains for the Treatment of Highly Alkaline Winery Wastewater." ACS ES&T Engineering (2023).

591) Pye, C. R., D. C. Green, J. R. Anderson, M. M. Phelan, M. M. Fitzgerald, E. J. Comerford, and M. J. Peffers. "Determining predictive metabolomic biomarkers of meniscal injury in dogs with cranial cruciate ligament rupture." Journal of Small Animal Practice (2023).

590) Payne, Joseph. "Metabolomic analysis of GM and non-GM maize and its preference by cattle." PhD diss.

589) Piccionello, Angela Palumbo, Sara Sassaroli, Luca Pennasilico, Giacomo Rossi, Alessandro Di Cerbo, Valentina Riccio, Caterina Di Bella et al. "Comparative study of 1H-NMR metabolomic profile of canine synovial fluid in patients affected by four progressive stages of spontaneous osteoarthritis." (2023).

588) Challa, Apoorva, Uma Sharma, Ritu Tyagi, Pawan Kumar, Seema Sood, Garima Kachhawa, Naranamangalam R. Jagannathan, and Somesh Gupta. "Predictive performance of 1H-NMR metabolomics derived biomarkers of bacterial vaginosis." Sexually Transmitted Diseases (2023): 10-1097.

587) Dudka, Ilona, Kristina Lundquist, Pernilla Wikström, Anders Bergh, and Gerhard Gröbner. "Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes." Journal of Translational Medicine 21, no. 1 (2023): 860.

586) Dhamija, Bhavuk, Soumitra Marathe, Vinanti Sawant, Moumita Basu, Diksha Attrish, Ditipriya Mukherjee, Sushant Kumar et al. "IL-17A Orchestrates Reactive Oxygen Species/HIF1α–Mediated Metabolic Reprogramming in Psoriasis." The Journal of Immunology (2023).

585) Correia, Banny Silva Barbosa, Søren D. Nielsen, Johanna Jorkowski, Louise Margrethe Arildsen Jakobsen, Christian Zacherl, and Hanne Christine Bertram. "Maillard Reaction Products and Metabolite Profile of Plant-Based Meat Burger Compared with Traditional Meat Burgers and Cooking-Induced Alterations." Available at SSRN 4647967.

584) Castro, Alex, Aparecida M. Catai, Patrícia Rehder-Santos, Étore F. Signini, Raphael Martins de Abreu, Claudio Donisete Da Silva, Carla Cristina Dato, Regina V. Oliveira, and Antônio G. Ferreira. "Insights into the Serum Metabolic Adaptations in Response to Inspiratory Muscle Training: A Metabolomic Approach Based on 1H NMR and UHPLC-HRMS/MS." International Journal of Molecular Sciences 24, no. 23 (2023): 16764.

583) Viana, Laís Rosa, Leisa Lopes-Aguiar, Rafaela Rossi Rosolen, Rogerio Willians dos Santos, and Maria Cristina Cintra Gomes-Marcondes. "H-NMR Based Serum Metabolomics Identifies Different Profile between Sarcopenia and Cancer Cachexia in Ageing Walker 256 Tumour-Bearing Rats."

582) Silva, Tatiana D., Célia Alves, Helena Oliveira, and Iola F. Duarte. "Biological Impact of Organic Extracts from Urban-Air Particulate Matter: An In Vitro Study of Cytotoxic and Metabolic Effects in Lung Cells." International Journal of Molecular Sciences 24, no. 23 (2023): 16896.

581) Zhao, Mantong, Mengru Yang, Jieyong Du, Xia Cao, Luyang Zhong, Wei Li, Ying Chen et al. "Monochasma savatieri Franch. protects against acute lung injury via α7nAChR-TLR4/NF-κB p65 signaling pathway based on integrated pharmacology analysis." Journal of Ethnopharmacology (2023): 117487.

580) Nolis, Pau. "Advances in NMR spectroscopy of small molecules in solution." (2023).

579) Bo, Yaping, Qing Yu, and Wenyuan Gao. "Progress of Depression Mechanism Based on Omics Method." Journal of Pharmaceutical and Biomedical Analysis (2023): 115884.

578) VALERIANO, QUÍMICO ALAN EMMANUEL AGUILAR. "MAESTRO EN CIENCIAS." PhD diss., UNIVERSIDAD NACIONAL AUTÓNOMA DE MEXICO, 2023.

577) Yoon, Dahye, Bo-Ram Choi, Woo Cheol Shin, Kwan-Woo Kim, Young-Seob Lee, and Dae Young Lee. "Metabolomics reveals that Curcuma longa and demethoxycurcumin inhibit HCT116 human colon cancer cell growth." Applied Biological Chemistry 66, no. 1 (2023): 1-10.

576) Frawley, Dean, Trinidad Velasco-Torrijos, and Fiona Walsh. "Improved workflow for untargeted metabolomics and NMR analysis of intracellular and extracellular metabolites isolated from Gram positive and Gram negative bacteria." bioRxiv (2023): 2023-11.

575) Legrand, Elena, Amanda L. Bayless, Daniel W. Bearden, Fabio Casu, Michael Edwards, Annie Jacob, W. Edward Johnson, and Tracey B. Schock. "Untargeted Metabolomics Analyses and Contaminant Chemistry of Dreissenid Mussels at the Maumee River Area of Concern in the Great Lakes." Environmental Science & Technology (2023).

574) Mäntyselkä, Sakari, Kalle Kolari, Philipp Baumert, Laura Ylä-Outinen, Lauri Kuikka, Suvi Lahtonen, Perttu Permi et al. "Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling." American Journal of Physiology-Endocrinology and Metabolism (2023).

573) Anjitha, K. S., Nair G. Sarath, P. P. Sameena, Edappayil Janeeshma, A. M. Shackira, and Jos T. Puthur. "Plant response to heavy metal stress toxicity: the role of metabolomics and other omics tools." Functional Plant Biology (2023).

572) Chaudhari, Sachin R., and Anisha Biswas. "Simplified Natural Sweetener Profiling by 1h Nmr Spectroscopy: Using Direct Proton Detection." Babasaheb baskarrao, Simplified Natural Sweetener Profiling by 1h Nmr Spectroscopy: Using Direct Proton Detection.

571) Casani, Augusto Pietro, Roberto Albera, Cristina Piras, Andrea Albera, Antonio Noto, Nicola Ducci, Luigi Atzori, Sergio Lucisano, Michele Mussap, and Vassilios Fanos. "Clinical Efficacy and Metabolomics Modifications Induced by Polyphenol Compound Supplementation in the Treatment of Residual Dizziness Following Repositioning Maneuvers in Benign Paroxysmal Positional Vertigo (BPPV)." (2023).

570) Matías, Javier, Maria Jose Rodriguez, Verónica Cruz, Patricia Calvo, Sara Granado-Rodríguez, Laura Poza-Viejo, Nieves Fernandez-Garcia, Enrique Olmos, and María Reguera. "Assessment of the changes in seed yield and nutritional quality of quinoa grown under rainfed Mediterranean environments." Frontiers in Plant Science 14 (2023).

569) Ferrari, Elena, Mariana Gallo, Alberto Spisni, Rita Antonelli, Marco Meleti, and Thelma A. Pertinhez. "Human Serum and Salivary Metabolomes: Diversity and Closeness." International Journal of Molecular Sciences 24, no. 23 (2023): 16603.

568) Viana, Laís Rosa, Leisa Lopes-Aguiar, Rafaela Rossi Rosolen, Rogerio Willians dos Santos, and Maria Cristina Cintra Gomes-Marcondes. "H-NMR Based Serum Metabolomics Identifies Different Profile between Sarcopenia and Cancer Cachexia in Ageing Walker 256 Tumour-Bearing Rats."

567) Lewis, Christopher TA, Elise G. Melhedegaard, Marija M. Ognjanovic, Mathilde S. Olsen, Jenni Laitila, Robert AE Seaborne, Magnus N. Gronset et al. "Remodelling of skeletal muscle myosin metabolic states in hibernating mammals." bioRxiv (2023): 2023-11.

566) Tian, Shuchang, Min Soo Kim, Jingcheng Zhao, Kerim Heber, Fuhua Hao, David Koslicki, Andrew D. Patterson, and Jordan E. Bisanz. "A Synthetic Microbiota Designed Through Meta-Analysis Provides Insight to Community Function in Clostridioides Difficile Resistance." Available at SSRN 4634354.

565) Srivastava, Jyotika, Rimjhim Trivedi, Pragati Saxena, Sanjeev Yadav, Ruchi Gupta, Soniya Nityanand, Dinesh Kumar, and Chandra P. Chaturvedi. "Bone marrow plasma metabonomics of idiopathic acquired aplastic anemia patients using 1H nuclear magnetic resonance spectroscopy." Metabolomics 19, no. 12 (2023): 94.

564) Oladosu, Oyekunle John, Banny Silva Barbosa Correia, Beatrice Grafl, Dieter Liebhart, Cornelia C. Metges, Hanne Christine Bertram, and Gürbüz Daş. "1H-NMR based-metabolomics reveals alterations in the metabolite profiles of chickens infected with ascarids and concurrent histomonosis infection." Gut Pathogens 15, no. 1 (2023): 1-12.

563) Lanctôt, Chantal, Laura F. Grogan, Kate Tunstill, and Steven D. Melvin. "Metabolomic response of striped marsh frog (Limnodynastes peronii) tadpoles exposed to the fire retardant Phos-Chek LC95W." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology (2023): 109786.

562) Abadl, M. M. T., A. A. Marzlan, R. Sulaiman, F. Abas, and A. S. Meor Hussin. "Optimization of Coconut Milk Kefir Beverage by RSM and Screening of Its Metabolites and Peptides. Fermentation 2023, 9, 430." (2023).

561) Damato, Anna. "SAFE USE OF BENTONITE IN DAIRY COWS. ASSESSMENT OF PHYSIOLOGICAL RESPONSES BY STUDYING METABOLOME AND MINERAL CONTENT IN BIOFLUIDS AND MILK CHARACTERISTICS." (2023).

560) Cabral, Vitor, Rita A. Oliveira, Margarida B. Correia, Miguel F. Pedro, Carles Ubeda, and Karina B. Xavier. "Novel gut probiotic engages microbiota for recovery and pathobiont clearance while preventing inflammation." bioRxiv (2023): 2023-11.

559) Iobbi, Valeria, Giuliana Donadio, Anna Paola Lanteri, Norbert Maggi, Johannes Kirchmair, Valentina Parisi, Giovanni Minuto et al. "Metabolite profiling of “Eretto Liguria”, an Italian local ecotype of Salvia rosmarinus, and antimicrobial activity against Pectobacterium carotovorum subsp. carotovorum." Planta Medica 89, no. 14 (2023): 1409-1409.

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82) Roin, Natacha Roed, Gayani Madushani Sirinayake Lokuge, Mads Bugge Fredsted, Ulrik Kræmer Sundekilde, Mette Krogh Larsen, Lotte Bach Larsen, and Nina Aagaard Poulsen. "Variations in Fatty Acids, Micronutrients and Metabolites in Discrete Production Lines of Danish Silo Milk from Large and Small Dairies." Micronutrients and Metabolites in Discrete Production Lines of Danish Silo Milk from Large and Small Dairies.

81) Sato, Shiho, Zhiqian Yu, Mai Sakai, Ikuko N. Motoike, Daisuke Saigusa, Ryo Hirayama, Yoshie Kikuchi et al. "Decreased β‐hydroxybutyrate and ketogenic amino acid levels in depressed human adults." European Journal of Neuroscience (2023).

80) AminiTabrizi, Roya, Nathalia Graf‐Grachet, Rosalie K. Chu, Jason G. Toyoda, David W. Hoyt, Rasha Hamdan, Rachel M. Wilson, and Malak M. Tfaily. "Microbial sensitivity to temperature and sulfate deposition modulates greenhouse gas emissions from peat soils." Global Change Biology (2023).

79) Kistner, Sina, Carina I. Mack, Manuela J. Rist, Ralf Krüger, Björn Egert, Nathalie Biniaminov, Ann Katrin Engelbert et al. "Acute effects of moderate vs. vigorous endurance exercise on urinary metabolites in healthy, young, physically active men—A multi-platform metabolomics approach." Frontiers in Physiology 14 (2023): 91.

78) Rivera-Pérez, Araceli, Roberto Romero-González, and Antonia Garrido Frenich. "Untargeted 1h Nmr-Based Metabolomics and Multi-Technique Data Fusion: A Promising Combined Approach for Geographical and Processing Authentication of Thyme by Multivariate Statistical Analysis." Available at SSRN 4353456.

77) Adebo, Janet Adeyinka, Chiemela Enyinnaya Chinma, Adetola Olubanke Omoyajowo, and Patrick Berka Njobeh. "Metabolomics and its application in fermented foods." In Indigenous Fermented Foods for the Tropics, pp. 361-376. Academic Press, 2023.

76) Ntambi, James M., Xueqing Liu, Maggie S. Burhans, Ahmed ALjohani, Ebru Selin Selen, Kalyesubula Mugagga, and Fariba Assadi-Porter. "Hepatic oleate regulates one-carbon metabolism during high carbohydrate feeding." Biochemical and Biophysical Research Communications (2023).

75) Gong, Mengjuan, Hailong Lu, Lixi Li, Meiqi Feng, and Zhongjie Zou. "Integration of transcriptomics and metabonomics revealed the protective effects of hemp seed oil against methionine–choline-deficient diet-induced non-alcoholic steatohepatitis in mice." Food & Function (2023).

74) Bacil, Gabriel P., Guilherme R. Romualdo, Priscila MFD Piagge, Daniel R. Cardoso, Mathieu Vinken, Bruno Cogliati, and Luís F. Barbisan. "Unraveling Hepatic Metabolomic Profiles and Morphological Outcomes in a Hybrid Model of NASH in Different Mouse Strains." Antioxidants 12, no. 2 (2023): 290.

73) Li, Da-Wei, Lei Bruschweiler-Li, Alexandar L. Hansen, and Rafael Brüschweiler. "DEEP Picker1D and Voigt Fitter1D: a versatile tool set for the automated quantitative spectral deconvolution of complex 1D-NMR spectra." Magnetic Resonance 4, no. 1 (2023): 19-26.

72) Settachaimongkon, Sarn, Kunaporn Homyog, Wanwimon Mekboonsonglarp, Pitikorn Soonoue, Theerawat Lerdamnuaylarp, Poonradit Prayoonpeeraput, Peter Kappel Theil, and Morakot Nuntapaitoon. "Dynamics of fatty acid and non-volatile polar metabolite profiles in colostrum and milk depending on the lactation stage and parity number of sows." Scientific Reports 13, no. 1 (2023): 1989.

71) Osthoff, Gernot, Irenie Wiese, and Francois Deacon. "African Elephant Milk Short Saccharide and Metabolite Composition and Their Changes over Lactation." Animals 13, no. 3 (2023): 544.

70) Chen, Daoyou, Wanchao Chen, Wen Li, Xinmeng Wen, Di Wu, Zhong Zhang, and Yan Yang. "Effects of Continuous Enzymolysis on the Umami Characteristics of Lentinula Edodes and the Flavor Formation Mechanism of Umami Peptides." Available at SSRN 4346347.

69) Bashirova, Narmin, David Poppitz, Nils Klüver, Stefan Scholz, Jörg Matysik, and A. Alia. "A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo." Scientific Reports 13, no. 1 (2023): 1891.

68) Harris, Hannah C., Noelia Pereira, Todor Koev, Yaroslav Z. Khimyak, Gleb E. Yakubov, and Frederick J. Warren. "The impact of psyllium gelation behaviour on in vitro colonic fermentation properties." Food Hydrocolloids (2023): 108543.

67) Barnett, Sarah E., Jenna Kenyani, Martina Tripari, Zohra Butt, Rudi Grosman, Francesca Querques, Liam Shaw et al. "BAP1 loss is associated with higher ASS1 expression in epithelioid mesothelioma: implications for therapeutic stratification." Mol Cancer Res (2023).

66) Pomary, Precious Kwadzo, Sara Eichau, Núria Amigó, Laura Barrios, Fuencisla Matesanz, Marta García-Valdecasas, Ioana Hrom, María Isabel García Sánchez, and Maria Luisa Garcia-Martin. "Multifaceted Analysis of Cerebrospinal Fluid and Serum from Progressive Multiple Sclerosis Patients: Potential Role of Vitamin C and Metal Ion Imbalance in the Divergence of Primary Progressive Multiple Sclerosis and Secondary Progressive Multiple Sclerosis." Journal of Proteome Research (2023).

65) Hao, Yuanpeng, Xiaoqi Guo, Wenying Zhang, Fei Xia, Meiyu Sun, Hui Li, Hongtong Bai, Hongxia Cui, and Lei Shi. "1H NMR–based metabolomics reveals the antimicrobial action of oregano essential oil against Escherichia coli and Staphylococcus aureus in broth, milk, and beef." LWT (2023): 114540.

64) Jansma, Jack, Nicola U. Thome, Markus Schwalbe, Anastasia Chrysovalantou Chatziioannou, Somayah S. Elsayed, Gilles van Wezel, Pieter van den Abbeele, Saskia van Hemert, and Sahar El Aidy. "Probiotics supplementation to adult human small intestinal stoma microbiota causes dynamic increase in the community resistance to perturbations and nutrient utilization." bioRxiv (2023): 2023-01.

63) Bruisten, Sylvia, Steven S. Witkin, and Antonella Marangoni. "Torquetenovirus in pregnancy: Correlation with vaginal microbiome, metabolome and pro-inflammatory cytokines." Women in Infectious Agents and Disease: 2022 16648714 (2023): 5.

62) Brunel, Mathilde. "Metabolites in fish and humans as a response to different food ingredients."

61) Young, Jonathan A., Silvana Duran-Ortiz, Stephen Bell, Kevin Funk, Yuan Tian, Qing Liu, Andrew D. Patterson, Edward O. List, Darlene E. Berryman, and John J. Kopchick. "Growth Hormone Alters Circulating Levels of Glycine and Hydroxyproline in Mice." Metabolites 13, no. 2 (2023): 191.

60) Shekher, Anusmita, Nikee Awasthee, Umesh Kumar, Ritu Raj, Dinesh Kumar, and Subash Chandra Gupta. "Association of altered metabolic profiles and long non-coding RNAs expression with disease severity in breast cancer patients: analysis by 1H NMR spectroscopy and RT-q-PCR." Metabolomics 19, no. 2 (2023): 8.

59) Zhang, Li, Ling Rong Wong, Peiyan Wong, Wanxiang Shen, Shili Yang, Lizhen Huang, Yun-An Lim, and Paul Chi-Lui Ho. "Chronic treatment with baicalein alleviates behavioural disorders and improves cerebral blood flow via reverting metabolic abnormalities in a J20 transgenic mouse model of Alzheimer's disease." Brain, Behavior, & Immunity-Health (2023): 100599.

58) Bacil, Gabriel P., Guilherme R. Romualdo, Priscila MFD Piagge, Daniel R. Cardoso, Mathieu Vinken, Bruno Cogliati, and Luís F. Barbisan. "Unraveling Hepatic Metabolomic Profiles and Morphological Outcomes in a Hybrid Model of NASH in Different Mouse Strains." Antioxidants 12, no. 2 (2023): 290.

57) Bennett, Samuel, Franck Brocherie, Marie M. Phelan, Eve Tiollier, Elodie Guibert, Antonio J. Morales‐Artacho, Paul Lalire, James P. Morton, Julien B. Louis, and Daniel J. Owens. "Acute heat stress amplifies exercise‐induced metabolomic perturbations and reveals variation in circulating amino acids in endurance‐trained males." Experimental Physiology (2023).

56) Sahoo, Bikash R., Alexandra A. Crook, Aryamav Pattnaik, Alondra D. Torres-Gerena, Oleh Khalimonchuk, Robert Powers, Rodrigo Franco, and Asit K. Pattnaik. "Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD (H) Antimetabolites." Journal of Virology (2023): e01363-22.

55) Bliziotis, N. G. B. "Untargeted Plasma Metabolomics of Endocrine Hypertension." PhD diss., [Sl]:[Sn], 2023.

54) Phelan, Marie M. "A review of online learning strategies for biological NMR techniques a survey of educators." bioRxiv (2023): 2023-01.

53) Kim, Hyun Sang, Shin Ja Lee, Jun Sik Eom, Youyoung Choi, Seong Uk Jo, Jaemin Kim, Sang Suk Lee, Eun Tae Kim, and Sung Sill Lee. "Comparison of metabolites in rumen fluid, urine, and feces of dairy cow from subacute ruminal acidosis model measured by proton nuclear magnetic resonance spectroscopy." Animal bioscience 36, no. 1 (2023): 53-62.

52) Zhao, Xin, Sarah L. Bridgman, Kelsea M. Drall, Hein M. Tun, Piush J. Mandhane, Theo J. Moraes, Elinor Simons et al. "Infant Vitamin D Supplements, Fecal Microbiota and Their Metabolites at 3 Months of Age in the CHILD Study Cohort." Biomolecules 13, no. 2 (2023): 200.

51) Christodoulou, Paris, Marigoula Vlassopoulou, Maria Zervou, Evangelos Xanthakos, Panagiotis Moulos, Georgios Koutrotsios, Georgios I. Zervakis et al. "In Vitro Fermentation of Pleurotus eryngii Mushrooms by Human Fecal Microbiota: Metataxonomic Analysis and Metabolomic Profiling of Fermentation Products." Journal of Fungi 9, no. 1 (2023): 128.

50) Christodoulou, P., M. Vlassopoulou, M. Zervou, E. Xanthakos, P. Moulos, G. Koutrotsios, G. I. Zervakis, E. N. Kerezoudi, E. K. Mitsou, and G. Saxami. "In Vitro Fermentation of Pleurotus eryngii Mushrooms by Human Fecal Microbiota: Metataxonomic Analysis and Metabolomic Profiling of Fermentation Products. J. Fungi 2023, 9, 128." (2023).

49) Villa, F., N. Ludwig, S. Mazzini, L. Scaglioni, A. L. Fuchs, B. Tripet, V. Copié, P. S. Stewart, and F. Cappitelli. "A desiccated dual-species subaerial biofilm reprograms its metabolism and affects water dynamics in limestone." Science of The Total Environment (2023): 161666.

48) Brown, Catherine LJ, Sarah JM Zaytsoff, Andrew N. Iwaniuk, Gerlinde AS Metz, Tony Montina, and G. Douglas Inglis. "Comparative Analysis of the Temporal Impacts of Corticosterone and Simulated Production Stressors on the Metabolome of Broiler Chickens." Metabolites 13, no. 2 (2023): 144.

47) Lan, Wenning, Xiaojing Zhang, Junhao Lin, Xiaolian Xiao, Junkun Chen, Shiying Sun, Guanlan Hong, Jingjing Nian, and Yun Zhang. "Physiochemical Responses of C. Elegans Under Exposure to Lanthanum and Cerium Affected by Bacterial Metabolism." Elegans Under Exposure to Lanthanum and Cerium Affected by Bacterial Metabolism.

46) Jeong, Jin-Hyuck, Jun-Seok Han, Youngae Jung, Seung-Min Lee, So-Hyun Park, Mooncheol Park, Min-Gi Shin et al. "A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity." Nature Communications 14, no. 1 (2023): 288.

45) Liu, Yanan, Miaomiao Chen, Xiaoquan Mu, Xinru Wang, Menghan Zhang, Yue Yin, and Kun Wang. "Responses and Detoxification Mechanisms of Earthworm Amynthas Hupeiensis to Metal Contaminated Soils of North China." Available at SSRN 4325888.

44) Cormier, Matt. "Characterization of natural anti-FVIII antibodies and the regulatory role of the gut microbiota in FVIII immunogenicity." PhD diss., 2023.

43) Cheney, Alexandra M., Stephanann M. Costello, Nicholas V. Pinkham, Annie Waldum, Susan C. Broadaway, Maria Cotrina-Vidal, Marc Mergy et al. "Gut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia." Nature Communications 14, no. 1 (2023): 1-12.

42) Ramappa, Venkatesh Kumar, Vandana Singh, Devika Srivastava, Devarsh Kumar, Anshika Verma, Darshika Verma, Eram Fatima, Priyanka Chaudhary, Umesh Kumar, and Dinesh Kumar. "Fabrication of mulberry leaf extract (MLE)-and tasar pupal oil (TPO)-loaded silk fibroin (SF) hydrogels and their antimicrobial properties." 3 Biotech 13, no. 2 (2023): 1-19.

41) Wee, Sze Ping, Khye Er Loh, Kok Wai Lam, and Intan Safinar Ismail. "A Study of the Interaction between Xanthine Oxidase and Its Inhibitors from Chrysanthemum morifolium Using Computational Simulation and Multispectroscopic Methods." Metabolites 13, no. 1 (2023): 113.

40) Chung, Yi-Hsiu, Tsai-Hsien Hung, Ching-Fang Yu, Cheng-Kun Tsai, Chi-Chang Weng, Fujie Jhang, Fang-Hsin Chen, and Gigin Lin. "Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive 18F-FDG PET/CT and Serum 1H-NMR Analysis: An Orthotopic Murine Model Study." Metabolites 13, no. 1 (2023): 110.

39) Cheon, Seongwon, Geonhee Kim, Jae-Han Bae, Dong Hyeon Lee, Hyunbin Seong, Hye Da Kim, Jung-Sook Han, Su-Youn Lim, and Nam Soo Han. "Comparative analysis of prebiotic effects of four oligosaccharides using in vitro gut model: digestibility, microbiome, and metabolome changes." FEMS Microbiology Ecology (2023).

38) Rodríguez-Hernández, Aida Araceli, Maricela Herrera-Alvarez, Diego Helman Zapata-Sarmiento, Elvia Becerra-Martínez, Mario Rodríguez-Monroy, and Gabriela Sepúlveda-Jiménez. "Trichoderma asperellum promotes the development and antioxidant activity of white onion (Allium cepa L.) plants." Horticulture, Environment, and Biotechnology (2023): 1-15.

37) Martínez-Nicolás, Juan José, Francisca Hernández, Dámaris Núñez-Gómez, Francisco García-Sánchez, Rafael Martínez-Font, Pilar Legua, and Pablo Melgarejo. "Metabolomic Approach to Study the ‘Purple Queen’Pomegranate Cultivar Response to Alternative Culture Media and Phenological Stages." Foods 12, no. 2 (2023): 352.

36) Pinto, Bruna Cristina, Adriana Barboza Alves, Osania Emerenciano Ferreira, Gustavo Henrique Gravatim Costa, Magno André de Oliveira, Augusto Cesar da Silva Bezerra, and Alan Rodrigues Teixeira Machado. "Biochar influences the cane fields’ microbiota and the development of pre-sprouted sugarcane seedlings." Waste Disposal & Sustainable Energy (2023): 1-14.

35) Mráziková, Lucia, Silvie Hojná, Petra Vaculová, Štěpán Strnad, Vladimír Vrkoslav, Helena Pelantová, Marek Kuzma, Blanka Železná, Jaroslav Kuneš, and Lenka Maletínská. "Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance." Nutrients 15, no. 2 (2023): 280.

34) Miebach, Lea, Hager Mohamed, Kristian Wende, Vandana Miller, and Sander Bekeschus. "Pancreatic Cancer Cells Undergo Immunogenic Cell Death upon Exposure to Gas Plasma-Oxidized Ringers Lactate." Cancers 15, no. 1 (2023): 319.

33) Lai, Giacomo, Pierluigi Caboni, Cristina Piras, Massimo Pes, Maria Sitzia, Margherita Addis, Antonio Pirisi, and Paola Scano. "Development and Chemico-Physical Characterization of Ovine Milk-Based Ingredients for Infant Formulae." Applied Sciences 13, no. 1 (2023): 653.

32) Tiepo, Angelica N., Isabel D. Coutinho, Guilherme O. Machado, Halley C. Oliveira, José Antonio Pimenta, Liliane Marcia M. Henning, Luiz Alberto Colnago, and Renata Stolf-Moreira. "Phenolic Compounds from Leaves of Cariniana estrellensis (Raddi) Kuntze (Lecythidaceae): A Brazilian Atlantic Forest Tree." Journal of the Brazilian Chemical Society 34 (2023): 146-152.

31) Palomares, Cristofher Victor Vivas, Yan Borges Barreto, Natalia Marchesan Bexiga, Sergio Hiroshi Toma, Jonnatan Julival dos Santos, Koiti Araki, Adriano Mesquita Alencar, and Antonio Carlos Bloise. "Metabolic Profiling of Murine Macrophages Exposed to Silver Nanoparticles at Dose and Time Dependencies." Particle & Particle Systems Characterization: 2200191.

30) McCauley, Heather A., Anne Marie Riedman, Jacob R. Enriquez, Xinghao Zhang, Miki Watanabe-Chailland, J. Guillermo Sanchez, Daniel O. Kechele et al. "Enteroendocrine cells protect the stem cell niche by regulating crypt metabolism in response to nutrients." Cellular and Molecular Gastroenterology and Hepatology (2023).

29) Sun, Jialin, Sivan Osenberg, Austin Irwin, Li-Hua Ma, Nigel Lee, Yangfei Xiang, Feng Li et al. "Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation." Cell Reports 42, no. 1 (2023): 111942.

28) Bouhajeb, Rim, Ana Cristina Abreu, Salima Selmi, Christoph Gerke, Ahlem Bellalah, Alexis Alvear-Jiménez, Laura Lozano Chamizo et al. "Implantable Electrospun Nanofibers with Wound-Healing Capabilities in the Reduction of Pressure Ulcers." ACS Applied Polymer Materials (2023).

27) Ganesan, Raja, Sang Jun Yoon, and Ki Tae Suk. "Microbiome and Metabolomics in Liver Cancer: Scientific Technology." International Journal of Molecular Sciences 24, no. 1 (2023): 537.

26) Zhang, Huan, Eric C. Johnson, Anne Carroll, Cecily Pryor, Kenneth Howe, Ryan Kramer, Naik Rajesh et al. "Profiling bourbons based on congener concentrations." Journal of Food Composition and Analysis 115 (2023): 105019.

25) Laketic, Katarina, Sophie Lalonde-Bester, Kim Smyth, Donna M. Slater, Suzanne C. Tough, Hiroaki Ishida, Hans J. Vogel, Gerald F. Giesbrecht, Chunlong Mu, and Jane Shearer. "Maternal Metabolites Indicative of Mental Health Status during Pregnancy." Metabolites 13, no. 1 (2023): 24.

24) Ruiz-Rico, María, Simone Renwick, Sarah J. Vancuren, Avery V. Robinson, Connor Gianetto-Hill, Emma Allen-Vercoe, and José M. Barat. "Impact of food preservatives based on immobilized phenolic compounds on an in vitro model of human gut microbiota." Food Chemistry 403 (2023): 134363.

23) Tripathi, Shweta, Manikyaprabhu Kairamkonda, Payal Gupta, and Krishna Mohan Poluri. "Dissecting the molecular mechanisms of producing biofuel and value-added products by cadmium tolerant microalgae as sustainable biorefinery approach." Chemical Engineering Journal 454 (2023): 140068.

22) Han, Dong Min, Ju Hye Baek, Byung Hee Chun, and Che Ok Jeon. "Fermentative features of Bacillus velezensis and Leuconostoc mesenteroides in doenjang-meju, a Korean traditional fermented soybean brick." Food Microbiology 110 (2023): 104186.

21) Baek, Ju Hye, Kyung Hyun Kim, Dong Min Han, Se Hee Lee, and Che Ok Jeon. "Effects of glutinous rice paste and fish sauce on kimchi fermentation." LWT 173 (2023): 114253.

20) Pereira, Tayla CS, Alzenir R. Souza, Paula B. Daltro, Maria GA Carosio, Antonio G. Ferreira, Regina V. Oliveira, Vitor Fortuna, and Paulo R. Ribeiro. "Blood plasma and bone marrow interstitial fluid metabolomics of sickle cell disease patients with osteonecrosis: An exploratory study to dissect biochemical alterations." Clinica Chimica Acta 539 (2023): 18-25.

19) Jiang, Lin, and Bo Wang. "Metabolomics study on southern hard clams (Mercenaria campechiensis) response to diclofenac exposure." Environmental Science: Advances (2023).

18) Bragulat, Ana P. Flores, Isabel Ortiz, Jaime Catalán, Jesus Dorado, Manuel Hidalgo, Luis Losinno, Marta Dordas-Perpinyà et al. "Time-lapse imaging and developmental competence of donkey eggs after ICSI: Effect of preovulatory follicular fluid during oocyte in vitro maturation." Theriogenology 195 (2023): 199-208.

17) Canella, Rita, Federica Brugnoli, Mariana Gallo, Jeffrey W. Keillor, Anna Terrazzan, Elena Ferrari, Silvia Grassilli et al. "A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10. 1 Voltage-Dependent K+ Channel in Breast Cancer." Cancers 15, no. 1 (2023): 178.

16) Lee, Sheng-Han, Zhi-Yi Du, Wei-Chen Tseng, Wan-Yu Lin, Mei-Huei Chen, Ching-Chun Lin, Hao-Jan Liang et al. "Identification of serum metabolic signatures of environmental-leveled phthalate in the Taiwanese child population using NMR-based metabolomics." Environmental Pollution 316 (2023): 120454.

15) Yim, Dong-Gyun, Hyun Jun Kim, Sung-Su Kim, Hag Ju Lee, Jae-Kyung Kim, and Cheorun Jo. "Effects of different X-ray irradiation doses on quality traits and metabolites of marinated ground beef during storage." Radiation Physics and Chemistry 202 (2023): 110563.

14) Kunc, Martin, Pavel Dobeš, Rachel Ward, Saetbyeol Lee, Radim Čegan, Silvie Dostálková, Kateřina Holušová et al. "Omics-based analysis of honey bee (Apis mellifera) response to Varroa sp. parasitisation and associated factors reveals changes impairing winter bee generation." Insect Biochemistry and Molecular Biology 152 (2023): 103877.

13) Zakaria, Fauziahanim, Muhammad Tayyab Akhtar, Wan Ibrahim Wan Norhamidah, Abu Bakar Noraini, Azira Muhamad, Shamarina Shohaimi, Hafandi Ahmad, Intan Safinar Ismail, Nor Hadiani Ismail, and Khozirah Shaari. "Centella asiatica (L.) Urb. Extract ameliorates branched-chain amino acid (BCAA) metabolism in acute reserpine-induced stress zebrafish model via 1H Nuclear Magnetic Resonance (NMR)-based metabolomics approach." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 264 (2023): 109501.

12) Silva, Andressa Kuhnen, Gerlon de Almeida Ribeiro Oliveira, Alex Castro, Cristiano Sales Prado, and Luciano Morais Lião. "The most consumed beef cuts in Brazil: Prices versus metabolic profile." Journal of Food Composition and Analysis 115 (2023): 104860.

11) Galvez-Fernandez, Marta, Zulema Rodriguez-Hernandez, Maria Grau-Perez, F. Javier Chaves, Ana Barbara Garcia-Garcia, Nuria Amigo, Daniel Monleon et al. "Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study." Free Radical Biology and Medicine 194 (2023): 52-61.

10) 赵楠, 孔媛, 张莹莹, 赵美蓉, 顾金苹, and 金航标. "基于 1 H NMR 的代谢组学方法研究 F-53B 暴露对大鼠血清代谢表型的影响." 环境化学: 1-9.

9) Singh, Sanjay, Sukanya Tripathy, Atul Rawat, Durgesh Dubey, Sarfraj Ahmad Siddiqui, Rajesh Ugale, Dinesh Kumar, and Anand Prakash. "Pre-clinical Investigations of Therapeutic Markers Associated with Acute and Chronic Restraint Stress: A Nuclear Magnetic Resonance Based Contrast Metabolic Approach." Nanotheranostics 7, no. 1 (2023): 91-101.

8) He, Ying, Bang Cheng, Bing-Jian Guo, Zheng Huang, Jing-Hua Qin, Qian-Yi Wang, Lin-Lin Feng et al. "Metabonomics and 16S rRNA gene sequencing to study the therapeutic mechanism of Danggui Sini decoction on collagen-induced rheumatoid arthritis rats with Cold Bi syndrome." Journal of Pharmaceutical and Biomedical Analysis 222 (2023): 115109.

7) Verlander, Jill W., Hyun-Wook Lee, Susan M. Wall, Autumn N. Harris, and I. David Weiner. "The proximal tubule through an NBCe1-dependent mechanism regulates collecting duct phenotypic and remodeling responses to acidosis." American Journal of Physiology-Renal Physiology 324, no. 1 (2023): F12-F29.

6) Damerau, Annelie, Eija Ahonen, Maaria Kortesniemi, Haraldur G. Gudmundsson, Baoru Yang, Gudmundur G. Haraldsson, and Kaisa M. Linderborg. "Docosahexaenoic acid in regio-and enantiopure triacylglycerols: Oxidative stability and influence of chiral antioxidant." Food Chemistry 402 (2023): 134271.

5) Cui, Chuanjian, Mingyue Xia, Ziqi Wei, Jianglin Chen, Chuanyi Peng, Huimei Cai, Long Jin, and Ruyan Hou. "1H NMR-based metabolomic approach combined with machine learning algorithm to distinguish the geographic origin of huajiao (Zanthoxylum bungeanum Maxim.)." Food Control 145 (2023): 109476.

4) Flügge, Friedemann, Tim Kerkow, Paulina Kowalski, Josephine Bornhöft, Eva Seemann, Marina Creydt, Burkhard Schütze, and Ulrich L. Günther. "Qualitative and quantitative food authentication of oregano using NGS and NMR with chemometrics." Food Control 145 (2023): 109497.

3) Sakallioglu, Isin Tuna, Bridget Tripp, Jacy Kubik, Carol A. Casey, Paul Thomes, and Robert Powers. "Multiomics Approach Captures Hepatic Metabolic Network Altered by Chronic Ethanol Administration." Biology 12, no. 1 (2023): 28.

2) Sundarrajan, Priya, and Lekha Bhagtaney. "Biotechnologically Engineered Transgenic Medicinal Plants: Exploration of Antidiabetic Properties." In Antidiabetic Potential of Plants in the Era of Omics, pp. 279-323. Apple Academic Press, 2023.

1) Huang, Feng, Tong Zhang, Bin Li, Shaosong Wang, Chang Xu, Caihua Huang, and Donghai Lin. "NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice." Journal of Ethnopharmacology 300 (2023): 115626.

Case Studies

The case studies below showcase various studies that were performed using Chenomx technology and services.

 

Analyzing the Metabolic Effects of Acetaminophen

 

Developing Biomarkers for Adverse Drug Responses

 

Pathways From Serological Metabolite Profiles

Acetaminophen is the most common identifiable cause of acute liver failure, and is an excellent model compound for studying liver toxicity. Acetaminophen toxicity has thus become a very active area of research. Identifying and quantifying metabolites associated with acetaminophen toxicity is an integral part of this research, and Chenomx is uniquely equipped to extract this information from biofluid samples.

Drug-induced liver injury is the leading reason that drug candidates fail. Identifying a suite of toxicity biomarkers for use in preclinical screening of drug candidates will allow drugs with harmful side effects to be identified earlier. Biomarkers that can be used to monitor or stage diseases will also offer insight into the net metabolic effect of a drug and can provide information for developing new drugs or adjusting treatment. Chenomx software offers powerful tools to aid in identifying these biomarkers.

Metabolomic data sets obtained using Chenomx NMR Suite often require additional analysis to place them in proper context. The GeneGo pathway analysis platform can help establish this context. In this note, we present an example analysis using serological metabolic profiles from Chenomx NMR Suite, known inflammatory markers from prior studies of the K/BxN mouse model and the GeneGo platform to generate a mechanistic hypothesis for the K/BxN mouse model.

Application Notes

Methods

Accurate CSI Quantification for Targeted Profiling

Accurately quantifying metabolites using targeted profiling in Chenomx NMR Suite requires using a chemical shape and shift indicator (CSI) of known concentration. As a result, the accuracy of the CSI concentration has a significant influence on quantification accuracy using this technique. Measuring ratios of the CSI peak area with that of a second, commercially available standard under optimal acquisition conditions offers a simple method of accurately measuring the concentration of the CSI.

 Optimizing Spectra for Metabolomics

Chenomx Processor allows you to work with NMR spectra from a variety of sources, helping you apply phasing and baseline correction through manual and semi-automated tools, and offering advanced lineshape correction through reference deconvolution. Processor also allows you to define chemical shape indicator (CSI) parameters and determine sample pH via indicator compounds. These are necessary prerequisites to analyzing your spectra with Chenomx Profiler.

Sample Types

Targeted Profiling of Common Metabolites in Saliva

Saliva is an excellent biofluid for analysis by targeted profiling. It is easily collected by individuals with minimal training, using noninvasive techniques. Targeted profiling of saliva samples can provide identification and quantification of many of the small molecule metabolites commonly found in saliva, and may allow the development of simple screening procedures for a variety of diseases. In this note we present a list of common metabolites found in human saliva, and techniques for targeted profiling of saliva spectra with Chenomx NMR Suite.

Metabolites in Blood Serum and Plasma

Blood serum and plasma are biofluids that are increasingly important in NMR-based metabolomics analysis. In this note we discuss several approaches to the analysis of serum using Chenomx NMR Suite, focusing on relaxation-edited NMR (CPMG) and physical separation of protein and metabolites using ultrafiltration. The CPMG method is simpler to apply, but the spectra are easier to analyze when protein is removed from a sample.

 

Targeted Profiling of Common Metabolites in Urine

Urine is a readily-collected, information-rich biofluid that can provide insight into the metabolic state of an organism. As a result, urine is often a focus in metabolomics investigations using NMR and MRI spectroscopy, in both diagnostic and monitoring applications. Targeted profiling is a powerful tool that can drive such studies, providing direct identification and quantification of a variety of metabolites. In this note we present a list of common metabolites found in many NMR spectra of human urine and several strategies for approaching targeted profiling of such spectra with Chenomx NMR Suite.

 

Identifying Metabolites in Biofluids

In this note we present a rapid, efficient method for identifying metabolites in biofluid NMR spectra using targeted profiling. Conventional techniques for identifying and quantifying metabolites in such spectra are labor-intensive and error-prone, as positions and linewidths of peaks can vary widely with changes in pH and other solution matrix effects. The length of time and level of operator skill needed to analyze large numbers of these complex spectra are significant barriers to the widespread application of NMR in metabolomics.

Statistical Analysis

Statistical Analysis of Targeted Profiling Data

Analysis of 1H NMR spectra in metabolomics studies often requires multivariate pattern recognition techniques to extract meaningful results. Targeted profiling offers the ability to analyze spectra based directly on the identity and quantities of individual compounds. Profiles created using targeted profiling in Chenomx NMR Suite can be used as input in statistical software packages such as Umetrics SIMCA-P. Performing PCA on Chenomx targeted profiles yields information-rich results that allow rapid biological interpretation, since group separation can be directly correlated to variations in specific metabolite concentrations.

Correcting Lineshapes in NMR Spectra

In this note we present a method for removing lineshape distortions from nuclear magnetic resonance (NMR) spectra prior to more detailed analysis. Reference deconvolution is a method of reconstructing an ideal spectrum by removing lineshape distortions caused by field inhomogeneity. Applying reference deconvolution has been found to improve the quality of fit of a spectrum using targeted profiling in Chenomx NMR Suite. However, successful application of reference deconvolution to a spectrum requires some preprocessing and the presence of an appropriate reference peak.

 

Statistical Analysis of Spectral Binning Data

Analysis of 1H NMR spectra in metabolomics studies often requires multivariate pattern recognition techniques to extract meaningful results. Spectral binning is an effective data reduction technique commonly used to prepare spectra for multivariate analysis. Spectral binning output from the Profiler module of Chenomx NMR Suite can readily be analyzed with multivariate analysis software packages like Umetrics SIMCA-P.